Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, Oita, 874-0838, Japan.
Aging Clin Exp Res. 2011 Feb;23(1):22-8. doi: 10.1007/BF03324949.
The telomere length of peripheral blood leukocytes has been reported to be inversely correlated with many kinds of pathophysiological conditions. However, correlations between telomere length in peripheral blood leukocytes and patients' physical ability are not known.
To address this problem, the physical ability of patients with cerebrovascular disease admitted to the chronic disease ward of Kyushu University Hospital was assessed with the Barthel index (BI) and the telomere length of their peripheral blood leukocytes was determined.
Women exhibited a significant correlation between the Barthel score and the expression of long telomeres (>9.4 Kb), in contrast with men who revealed no such correlation. The physical ability of older women was positively correlated with the lengths of their somatic telomeres. Among the BI items, the scores of more difficult physical performances tended to correlate with the presence of terminal restriction fragments longer than 9.4 Kb.
外周血白细胞的端粒长度与许多病理生理状况呈负相关。然而，外周血白细胞的端粒长度与患者的身体能力之间的相关性尚不清楚。
为了解决这个问题，评估了九州大学医院慢性病病房的脑血管病患者的身体能力，使用巴氏指数（BI）和外周血白细胞的端粒长度来评估。
与男性相比，女性的巴氏评分与长端粒（>9.4 Kb）的表达呈显著相关性，而男性则没有这种相关性。年长女性的身体能力与体细胞端粒的长度呈正相关。在 BI 项目中，更困难的身体表现的评分往往与 9.4 Kb 以上的末端限制片段的存在相关。
