Department of Ophthalmology, Ruijin Hospital Affiliated Medical School, Shanghai Jiaotong University, Shanghai, China.
Cornea. 2011 Aug;30(8):861-4. doi: 10.1097/ICO.0b013e3182000c27.
To compare the effects of latanoprost, travoprost, and bimatoprost on central corneal thickness (CCT).
A total of 69 eyes of 69 patients with glaucoma or ocular hypertension submitted to monotherapy with prostaglandin analogues (latanoprost 0.005%, travoprost 0.004%, or bimatoprost 0.03%) during a mean of 17.19 ± 15.71 months follow-up period. Measurements were performed at the initial diagnosis and at the end of follow-up. All the measurements were carried out by the same doctor between 9 am and 11 am, using Goldmann applanation tonometer for intraocular pressure and ultrasonic pachymetry for CCT.
A statistically significant reduction in CCT was observed in all groups (P < 0.001). The reduction of CCT in the latanoprost, travoprost, and bimatoprost groups was 14.95 ± 5.04, 15.73 ± 3.25, and 17.00 ± 6.23 μm, respectively. No significant difference was found in the reduction of CCT among the 3 groups (P > 0.05). No significant difference was also found in the reduction of CCT between the patients with less than or equal to 6 months' treatment and the patients with more than 6 months' treatment in the 3 groups (P > 0.05).
Topical therapy with prostaglandin analogues is associated with CCT reduction. Latanoprost, travoprost, and bimatoprost have a similar effect on CCT.
比较拉坦前列素、曲伏前列素和贝美前列素对中央角膜厚度（CCT）的影响。
69 例青光眼或高眼压患者共 69 眼，接受前列腺素类似物单药治疗（拉坦前列素 0.005%、曲伏前列素 0.004%或贝美前列素 0.03%），平均随访 17.19±15.71 个月。在初始诊断时和随访结束时进行测量。所有测量均由同一位医生在上午 9 点至 11 点之间使用 Goldmann 压平眼压计进行眼压测量和超声角膜测厚仪进行 CCT 测量。
所有组的 CCT 均显著降低（P<0.001）。拉坦前列素、曲伏前列素和贝美前列素组的 CCT 降低分别为 14.95±5.04、15.73±3.25 和 17.00±6.23μm。3 组间 CCT 降低无显著差异（P>0.05）。3 组中治疗时间少于或等于 6 个月的患者与治疗时间超过 6 个月的患者之间的 CCT 降低也无显著差异（P>0.05）。
前列腺素类似物的局部治疗与 CCT 降低有关。拉坦前列素、曲伏前列素和贝美前列素对 CCT 有相似的作用。
