唐氏综合征中的红细胞抗氧化系统。

Erythrocyte antioxidant system in Down syndrome.

作者信息

Gerli G, Zenoni L, Locatelli G F, Mongiat R, Piattoni F, Orsini G B, Montagnani A, Gueli M R, Gualandri V

机构信息

Clinica Medica V, Ospedale San Paolo, Milan, Italy.

出版信息

Am J Med Genet Suppl. 1990;7:272-3. doi: 10.1002/ajmg.1320370754.

DOI:10.1002/ajmg.1320370754

PMID:2149961

Abstract

It has been emphasized that an increased oxidative damage can exist in Down syndrome (DS), and that superoxide dismutase (SOD-1) seems to play a role in the pathogenesis of this disorder. We have studied the antioxidant system SOD-1, catalase, glutathione peroxidase (GSH-Px) and reduced glutathione (GSH) in erythrocytes of DS adults in order to evaluate if these cells are protected against oxidant stress. SOD-1 and GSH-Px were significantly increased while catalase and GSH activities were normal. These results suggest that the erythrocytes of these individuals have an unbalanced antioxidant system which may participate in the manifestations of DS.

摘要

已有研究强调，唐氏综合征（DS）患者体内可能存在氧化损伤增加的情况，且超氧化物歧化酶（SOD-1）似乎在该疾病的发病机制中发挥作用。我们研究了成年DS患者红细胞中的抗氧化系统，包括SOD-1、过氧化氢酶、谷胱甘肽过氧化物酶（GSH-Px）和还原型谷胱甘肽（GSH），以评估这些细胞是否能抵御氧化应激。结果显示，SOD-1和GSH-Px显著增加，而过氧化氢酶和GSH的活性正常。这些结果表明，这些个体的红细胞具有失衡的抗氧化系统，这可能参与了DS的临床表现。