Piro E, Pennino C, Cammarata M, Corsello G, Grenci A, Lo Giudice C, Morabito M, Piccione M, Giuffrè L
Cattedra di Patologia Neonatale, Istituto Materno-Infantile Università di Palermo, Italia.
Am J Med Genet Suppl. 1990;7:66-70. doi: 10.1002/ajmg.1320370712.
We present the results of a study performed on a Sicilian population of children with Down syndrome (DS) 0-14 years of age, observed between 1977 and 1988. Data from the present report concern 382 subjects with nonmosaic 21 trisomy, including 239 males (62.6%) and 143 females (37.4%). We excluded all DS children observed in the same period with associated pathology (congenital heart defects, gastrointestinal malformations, malabsorption, hypothyroidism, and thalassemia). Overall, 1,464 measurements were performed of length or height, weight, and head circumference. Means and standard deviation (SD) were calculated for all of these parameters. Our data confirm a trend toward a progressive improvement of growth in children with DS, as shown in other recent reports. The purpose of this study was also to create a "normal growth pattern" useful to evaluate DS children and also to diagnose early pathologic conditions affecting growth, such as autoimmune diseases.
我们展示了一项针对西西里岛0至14岁唐氏综合征（DS）儿童的研究结果，该研究于1977年至1988年期间进行。本报告的数据涉及382名非嵌合型21三体患儿，其中包括239名男性（62.6%）和143名女性（37.4%）。我们排除了同期观察到的所有伴有相关病理情况（先天性心脏病、胃肠道畸形、吸收不良、甲状腺功能减退和地中海贫血）的唐氏综合征患儿。总体而言，共进行了1464次身长或身高、体重和头围测量。计算了所有这些参数的均值和标准差（SD）。我们的数据证实了唐氏综合征患儿生长呈逐步改善的趋势，正如其他近期报告所示。本研究的目的还在于建立一种“正常生长模式”，以用于评估唐氏综合征患儿，并早期诊断影响生长的病理状况，如自身免疫性疾病。
