Child Growth & Anthropology Unit, Department of Pediatrics, Postgraduate Institute of Medical Education & Research (PGIMER), Chandigarh, India.
Genetics & Metabolic Unit, Department of Pediatrics, Postgraduate Institute of Medical Education & Research (PGIMER), Chandigarh, India.
Am J Med Genet A. 2024 Jul;194(7):e63571. doi: 10.1002/ajmg.a.63571. Epub 2024 Feb 22.
Age and gender specific growth charts for Indian children with Down syndrome (DS) based on longitudinal data have not been published. To establish percentile growth charts for DS children inhabiting northwestern parts of India, body weight and length/height of 1125 (Male: 752, Female: 373) children with DS aged <1 month to 10 years, enrolled from the "Genetics Clinic" were measured at half yearly age intervals in the "Growth Clinic" of the Institute from August 1994 to November 2018. A total of 2089 observations were made on these children using standardized anthropometric techniques and instruments following a prospective mixed-longitudinal growth research design. Using the LMS method, age and sex-specific percentile growth charts (<1 month to 10 years) for weight, and length/ height were generated. Unpaired t-test was used to compare mean growth attainments of study children with those of DS patients representing other population groups as well as their normal Multicentre Growth Reference Study (MGRS and Indian Academy of Pediatrics (IAP) counterparts. The 50th percentile growth curves for both weight and length/height of Indian children with DS demonstrated a regular increase. As compared to their normal MGRS and Indian (IAP) counterparts, the children with DS had lower weight and height attainments. The boys and girls with Down syndrome showed short stature (height < 3rd centile) from the age of 1 year till 10 years and also became underweight beyond 5 years. As compared to their normal counterparts, children with Down syndrome exhibited compromised auxological attainments. The use of growth charts presented herein may be used to compare and monitor growth and nutritional status of Indian children with Down syndrome.
目前尚未发表基于纵向数据的针对印度唐氏综合征（Down syndrome，DS）儿童的年龄和性别特异性生长图表。为了建立居住在印度西北部的 DS 儿童的百分位生长图表，我们对半岁至 10 岁的 1125 名（男：752 名，女：373 名）DS 儿童的体重和身长/身高进行了测量，这些儿童是在 1994 年 8 月至 2018 年 11 月期间，从“遗传学诊所”招募到我们研究所的“生长诊所”的。在一项前瞻性混合纵向生长研究设计中，使用标准化的人体测量技术和仪器，每半年对这些儿童进行一次测量，共对这些儿童进行了 2089 次测量。使用 LMS 方法，生成了体重和身长/身高的年龄和性别特异性百分位生长图表（<1 个月至 10 岁）。使用独立样本 t 检验比较了研究儿童的平均生长水平与其他人群 DS 患者以及他们的正常多中心生长参考研究（Multicentre Growth Reference Study，MGRS）和印度儿科学会（Indian Academy of Pediatrics，IAP）对照组的生长水平。印度 DS 儿童的体重和身长/身高的第 50 百分位生长曲线显示出稳定的增长。与他们的正常 MGRS 和印度（IAP）对照组相比，DS 儿童的体重和身高增长水平较低。患有唐氏综合征的男孩和女孩从 1 岁到 10 岁身高都低于第 3 百分位，并且 5 岁后体重也不足。与他们的正常对照组相比，唐氏综合征患儿的生长发育指标较差。本研究中提供的生长图表可用于比较和监测印度唐氏综合征儿童的生长和营养状况。
