[血浆二十二碳六烯酸水平改变在视网膜色素变性发病机制中的可能作用。初步结果]
[Possible role of altered levels of plasma docosahexaenoic acid in the pathogenesis of retinitis pigmentosa. Preliminary results].
作者信息
Simonelli F, Milone A, Iura A, Picardi C, La Banca A M, Cotticelli L, Rinaldi E
机构信息
Clinica Oculistica della I Facoltà di Medicina e Chirurgia Università di Napoli.
出版信息
Boll Soc Ital Biol Sper. 1990 Sep;66(9):893-8.
Plasma samples obtained from Retinitis Pigmentosa (R.P.) patients and controls were assayed for docosahexaenoic acid (DXA), the major fatty acid in photoreceptor cells, in order to evaluate the possibility that abnormalities in PUFA metabolism could be involved in R.P. pathogenesis. Our preliminary results show levels of plasma DXA in dominantly inherited R.P. lower than in the recessive forms and controls.
从视网膜色素变性（R.P.）患者和对照组获取血浆样本，检测其中光感受器细胞中的主要脂肪酸二十二碳六烯酸（DXA），以评估多不饱和脂肪酸（PUFA）代谢异常可能参与R.P.发病机制的可能性。我们的初步结果显示，显性遗传R.P.患者血浆DXA水平低于隐性遗传形式患者和对照组。
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