Adrenomedullin plasma concentrations in patients with retinitis pigmentosa.

作者信息

Vingolo E M, Lupo S, Domanico D, Cotesta D, Petramala L, Grenga R, Letizia C

机构信息

Department of Ophthalmology, University of Rome La Sapienza, Rome, Italy.

出版信息

Clin Biochem. 2005 Aug;38(8):735-8. doi: 10.1016/j.clinbiochem.2005.04.007.

PURPOSE

To evaluate the relationship between retinitis pigmentosa (RP) and plasma adrenomedullin (ADM) levels.

METHODS

Blood samples were obtained from a group of 40 consecutive patients with RP matched with 35 healthy subjects (HS) as control. We carried out a complete ophtalmological examination. The study group included 26 patients with RP and 14 patients with syndromic RP. Plasma ADM levels were determined in duplicate with a specific radioimmunoassay method.

RESULTS

In the HS plasma ADM levels were 13.7 +/- 6.1 pg/mL. The mean of plasma ADM concentrations in all patients with RP (23.4 +/- 10.7 pg/mL) was significantly (P < 0.0001) higher than that of HS. Moreover, in the syndromic RP patients, plasma ADM levels (28.6 +/- 14.35 pg/ml) were higher than those of HS and RP patients (P < 0.0017).

CONCLUSION

The increase of plasma ADM levels in RP patients may be a response to photoreceptor damage.