Dehkordi Mahboobeh Adami, Abolbashari Samaneh, Taheri Reza, Einolghozati Sasan
The Department of Otolaryngology, Islamic Azad University, Mashhad Branch, Mashhad, Iran.
Ear Nose Throat J. 2011 Apr;90(4):150-8. doi: 10.1177/014556131109000405.
Tinnitus can cause extreme morbidity. Despite many attempts to find a treatment for idiopathic cases, they remain difficult to manage. Because nerve injury is one of the suspected etiologies of tinnitus and because gabapentin has been found to be effective in treating nerve injuries, some authors have attempted to determine if gabapentin has a role in treating tinnitus. Although gabapentin was found to be ineffective for tinnitus in these previous studies, to the best of our knowledge no studies have been performed that took into consideration the presence of various accompanying factors and concomitant diseases that might influence its effect. We conducted a prospective, randomized, double-blind, placebo-controlled clinical trial of gabapentin for idiopathic tinnitus. We treated 40 patients with gabapentin and measured its effectiveness by comparing differences between pre- and post-treatment Tinnitus Severity Index (TSI) values and tinnitus loudness scores. We also compared these outcomes with those of a group of 40 matched placebo controls. At study's end, we found no significant differences between the gabapentin and control groups in mean decreases in TSI value and loudness score (p=0.85 and p=0.12, respectively). However, we did find that patients with hypertension, diabetes, and/or dyslipidemia showed a better response to gabapentin than did those with tinnitus alone (p=0.01). We conclude that although there was no statistically significant difference between gabapentin and placebo in treating isolated tinnitus or tinnitus overall, patients with concomitant hypertension, diabetes, and/or dyslipidemia may benefit from gabapentin.
耳鸣可导致严重的发病率。尽管人们多次尝试寻找特发性耳鸣的治疗方法，但这些病例仍然难以处理。由于神经损伤是耳鸣的疑似病因之一，且已发现加巴喷丁在治疗神经损伤方面有效，一些作者试图确定加巴喷丁在治疗耳鸣方面是否有作用。尽管在这些先前的研究中发现加巴喷丁对耳鸣无效，但据我们所知，尚未进行过考虑可能影响其效果的各种伴随因素和合并疾病的研究。我们对加巴喷丁治疗特发性耳鸣进行了一项前瞻性、随机、双盲、安慰剂对照的临床试验。我们用加巴喷丁治疗了40名患者，并通过比较治疗前后耳鸣严重程度指数（TSI）值和耳鸣响度评分的差异来衡量其有效性。我们还将这些结果与一组40名匹配的安慰剂对照者的结果进行了比较。在研究结束时，我们发现加巴喷丁组和对照组在TSI值和响度评分的平均降低方面没有显著差异（分别为p = 0.85和p = 0.12）。然而，我们确实发现患有高血压、糖尿病和/或血脂异常的患者对加巴喷丁的反应比单纯耳鸣患者更好（p = 0.01）。我们得出结论，尽管加巴喷丁和安慰剂在治疗孤立性耳鸣或总体耳鸣方面没有统计学上的显著差异，但伴有高血压、糖尿病和/或血脂异常的患者可能从加巴喷丁中获益。
