Kikidis Dimitrios, Vassou Evgenia, Schlee Winfried, Iliadou Eleftheria, Markatos Nikolaos, Triantafyllou Aikaterini, Langguth Berthold
First Department of Otorhinolaryngology, Head and Neck Surgery, Hippokration General Hospital, National and Kapodistrian University of Athens, 15772 Athens, Greece.
Department of Psychiatry and Psychotherapy, Universität Regensburg, 93053 Regensburg, Germany.
J Clin Med. 2021 Apr 16;10(8):1737. doi: 10.3390/jcm10081737.
Although a wide range of tinnitus management interventions is currently under research and a variety of therapeutic interventions have already been applied in clinical practice, no optimal and universal tinnitus treatment has been reached yet. This fact is to some extent a consequence of the high heterogeneity of the methodologies used in tinnitus related clinical studies. In this manuscript, we have identified, summarized, and critically appraised tinnitus-related randomized clinical trials since 2010, aiming at systematically mapping the research conducted in this area. The results of our analysis of the 73 included randomized clinical trials provide important insight on the identification of limitations of previous works, methodological pitfalls or gaps in current knowledge, a prerequisite for the adequate interpretation of current literature and execution of future studies.
尽管目前有广泛的耳鸣管理干预措施正在研究中，并且各种治疗干预措施已经应用于临床实践，但尚未找到最佳的通用耳鸣治疗方法。这一事实在一定程度上是耳鸣相关临床研究中所使用方法高度异质性的结果。在本手稿中，我们识别、总结并批判性地评估了自2010年以来的耳鸣相关随机临床试验，旨在系统地梳理该领域的研究情况。我们对73项纳入的随机临床试验的分析结果为识别先前研究的局限性、方法陷阱或当前知识空白提供了重要见解，这是充分解读当前文献和开展未来研究的先决条件。
