Dumăchiţă-Gargu Gabriela, Pricop Florentina
Universităţii de Medicină si Farmacie Gr.T. Popa Iaşi.
Rev Med Chir Soc Med Nat Iasi. 2010 Oct-Dec;114(4):1070-6.
The Polycystic Ovarian Syndrome is one of the most frequent of the endocrinopathies, affecting in average 8% of the woman's that are in to reproductive age. It was first described by Chereau and Rokitanski, further associated with the amenorrhea encountered in the Stein and Levanthal syndrome, exposed by the Irving F, Stein and Michael Leventhal, in 1935. In many aspects this is a systemic disease also interfering with the process of reproduction. The studies of the genetic factor implication, by relating with the specialty literature, converging with a series of hypotesys launch over the years, show a poligenic affliction or a combination of the environment with the genetics factors. Due to the fact that this syndrome is the most frequently encountered cause of infertility among women's, with a very complex etiopathogeny, the comprehension of it, is most important, because the Polycystic Ovarian Syndrome is a metabolic long term disorder. The study of the genetic act implications is a name part in prophylaxis of the appearance of this syndrome or its complications.
多囊卵巢综合征是最常见的内分泌疾病之一,平均影响8%处于生育年龄的女性。它最初由谢罗和罗基坦斯基描述,后来与斯坦因和莱文塔尔综合征中出现的闭经相关联,该综合征由欧文·F·斯坦因和迈克尔·莱文塔尔于1935年提出。在许多方面,这是一种全身性疾病,也会干扰生殖过程。通过与专业文献相关联的对遗传因素影响的研究,与多年来提出的一系列假设相一致,表明这是一种多基因疾病,或是环境与遗传因素的组合。由于该综合征是女性中最常见的不孕原因,其病因发病机制非常复杂,对其进行理解非常重要,因为多囊卵巢综合征是一种长期的代谢紊乱疾病。对遗传作用影响的研究在预防该综合征或其并发症的出现中起着重要作用。