Li Chua-wei, Chen Yu-cheng, Xiao Wen-wen, Liu Rui, Li Xian, Zeng Zhi
Department of Cardiology, West China Hospital, Sichuan University, Chengdu 610041, China.
Sichuan Da Xue Xue Bao Yi Xue Ban. 2011 Mar;42(2):245-8.
To investigate the association between coronary heart diseases and single nucleotide polymorphism (SNP) in rs174570 in Han Chinese Populations.
A case-control study was undertaken in Han Chinese in Sichuan province, with 264 patients with coronary heart diseases and 303 normal controls. The genotypes of SNP in rs174570 were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).
The genotypes of CC/CT/TT were detected in both case and control groups. No significant differences in the frequencies of the three genotypes were found between the two groups. The qualitative and quantitative analyses of the coronary angiography showed no significant differences in the patients with coronary heart diseases with the three genotypes. In the normal controls, high frequencies of C allele were associated with higher levels of low density lipoprotein cholesterol (LDL-C) and total cholesterol (TC) (P < 0.05).
Genetic polymorphism in rs174570 is not associated with the development and severity of coronary heart diseases despite its influences on serum LDL-C levels in Han Chinese Populations.
探讨汉族人群中冠心病与rs174570单核苷酸多态性（SNP）之间的关联。
在四川省汉族人群中进行病例对照研究，纳入264例冠心病患者和303例正常对照。采用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）法检测rs174570的SNP基因型。
病例组和对照组均检测到CC/CT/TT基因型。两组间三种基因型频率无显著差异。冠状动脉造影的定性和定量分析显示，三种基因型的冠心病患者之间无显著差异。在正常对照中，C等位基因的高频率与低密度脂蛋白胆固醇（LDL-C）和总胆固醇（TC）水平升高相关（P<0.05）。
尽管rs174570的基因多态性对汉族人群血清LDL-C水平有影响，但与冠心病的发生和严重程度无关。
