[Association of single nucleotide polymorphism in rs174570 with coronary heart diseases in Han Chinese populations].

OBJECTIVE

To investigate the association between coronary heart diseases and single nucleotide polymorphism (SNP) in rs174570 in Han Chinese Populations.

METHODS

A case-control study was undertaken in Han Chinese in Sichuan province, with 264 patients with coronary heart diseases and 303 normal controls. The genotypes of SNP in rs174570 were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).

RESULTS

The genotypes of CC/CT/TT were detected in both case and control groups. No significant differences in the frequencies of the three genotypes were found between the two groups. The qualitative and quantitative analyses of the coronary angiography showed no significant differences in the patients with coronary heart diseases with the three genotypes. In the normal controls, high frequencies of C allele were associated with higher levels of low density lipoprotein cholesterol (LDL-C) and total cholesterol (TC) (P < 0.05).

CONCLUSIONS

Genetic polymorphism in rs174570 is not associated with the development and severity of coronary heart diseases despite its influences on serum LDL-C levels in Han Chinese Populations.