[成都2型糖尿病患者一级亲属中糖尿病及糖尿病前期的患病率]

[Prevalence of diabetes and prediabetes mellitus in the first-degree relatives of patients with type 2 diabetes in Chengdu].

作者信息

Ma Hong, Gong Yuan, Liu Yuan-yuan, Song Jie, Tian Hao-ming, Chen Tao, Ran Xing-wu, Yu Hong-ling, Zhang Xiang-xun, Ren Yan

机构信息

Division of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu 610041, China.

出版信息

Sichuan Da Xue Xue Bao Yi Xue Ban. 2011 Mar;42(2):264-8.

PMID:21500569

Abstract

OBJECTIVE

To investigate the prevalence of diabetes and prediabetes mellitus in the first-degree relatives (FDR) of patients with type 2 diabetes (T2DM) in Chengdu.

METHODS

A cross-sectional study was undertaken in Chengdu. A total of 2306 adults were recruited, including 535 FDR of T2DM patients and 1771 people without a family history of diabetes. All participants received glucose tolerance tests and measurements of waist, blood pressure and blood lipids.

RESULTS

(1) The FDR of T2DM patients had greater standardized prevalence of diabetes than those without a family history of diabetes (26.6% vs. 9.2%). The standardized prevalence of prediabetes in these two groups was 15.0% and 14.1%, respretively. (2) Greater standardized prevalence of diabetes were found in both female (25.5%) and male (28.5%) FDR of T2DM patients compared with their counterparts without a family history of diabetes (women 8.7%, men 11.2%). The standardized prevalence of prediabetes between those with and without a family history of diabetes was 15.9% and 13.4% in women, 13.7% and 15.3% in men, respretively. (3) The younger than 40 years old FDR of T2DM patients had greater prevalence of diabetes and prediabetes than their counterpart without a family history of diabetes, while the FDR of T2DM with an age of > or =40 years old had greater prevalence of diabetes than their counterparts only (P > 0.05). The FDR of T2DM patients with <25 kg/m2 body mass index (BMI) had greater prevalence of diabetes and prediabetes than their counterparts without a family history of diabetes (25.1% vs. 7.4%, 13.2% vs. 9.3%, P < 0.05). The FDR of T2DM patients with > or = 25 kg/m2 BMI had greater prevalence of diabetes (33.0% vs. 13.7%, P < 0.05) but less prevalence of prediabetes (19.2% vs. 26.8%, P < 0.05) than their counterparts without a family history of diabetes. (4) The logistic regression showed that triglyceride (TG) was a risk factor for diabetes in those FDR of T2DM patients (OR = 1.363) and those without a family history of diabetes (OR = 1.27), and high density lipoprotein cholesterol (HDL-C) was a protective factor for diabetes in those without a family history of diabetes (OR = 0.546).

CONCLUSION

The FDR of T2DM patients have high risk of diabetes and those younger than 40 years or with <25 kg/m2 BMI also have high risk of prediabetes.

摘要

目的

调查成都地区2型糖尿病（T2DM）患者一级亲属（FDR）中糖尿病及糖尿病前期的患病率。

方法

在成都开展一项横断面研究。共招募2306名成年人，其中包括535名T2DM患者的FDR和1771名无糖尿病家族史者。所有参与者均接受葡萄糖耐量试验，并测量腰围、血压和血脂。

结果

（1）T2DM患者的FDR中糖尿病的标准化患病率高于无糖尿病家族史者（26.6%对9.2%）。这两组中糖尿病前期的标准化患病率分别为15.0%和14.1%。（2）T2DM患者的女性FDR（25.5%）和男性FDR（28.5%）中糖尿病的标准化患病率均高于无糖尿病家族史的女性（8.7%）和男性（11.2%）。有和无糖尿病家族史者中糖尿病前期的标准化患病率在女性中分别为15.9%和13.4%，在男性中分别为13.7%和15.3%。（3）T2DM患者中年龄小于40岁的FDR糖尿病及糖尿病前期的患病率高于无糖尿病家族史者，而年龄≥40岁的T2DM患者的FDR仅糖尿病患病率高于无糖尿病家族史者（P>0.05）。体重指数（BMI）<25kg/m2的T2DM患者的FDR糖尿病及糖尿病前期的患病率高于无糖尿病家族史者（25.1%对7.4%，13.2%对9.3%，P<0.05）。BMI≥25kg/m2的T2DM患者的FDR糖尿病患病率高于无糖尿病家族史者（33.0%对13.7%，P<0.05），但糖尿病前期患病率低于无糖尿病家族史者（19.2%对26.8%，P<0.05）。（4）逻辑回归显示，甘油三酯（TG）是T2DM患者的FDR（OR=1.363）及无糖尿病家族史者（OR=1.27）患糖尿病的危险因素，高密度脂蛋白胆固醇（HDL-C）是无糖尿病家族史者患糖尿病的保护因素（OR=0.546）。