De Zoysa Warsha, Weerarathna Thilak Priyantha, Wasana Keddagoda Gamage Piyumi, Weerarathna Miyuru Kavinda, Senadeera Vidarsha
Department of Medicine, Faculty of Medicine, University of Ruhuna, Galle, Sri Lanka.
Diabetes Centre, Cooperative Hospital, Galle, Sri Lanka.
Diabetol Metab Syndr. 2024 Jul 11;16(1):158. doi: 10.1186/s13098-024-01394-w.
Parental history of diabetes is an established risk factor for type 2 diabetes mellitus (T2DM). There is limited data on the association of parental history with the prevalence of T2DM in Sri Lanka. The study aims to examine the prevalence and correlation of parental history and factors such as the onset age, glycaemic control, and self-reported dietary compliance among T2DM patients. With a rising incidence of T2DM in Sri Lanka, understanding the impact of parental history on age at diagnosis and glycemic control can aid in targeted screening and interventions.
A cross-sectional study was carried out on 500 T2DM patients attending a diabetes clinic in Galle, the capital of Southern Sri Lanka with a multiethnic population. Convenient sampling strategy was followed in the recruitment process and a questionnaire-based method was used to collect the data. All the collected data was analysed using SPSS V 25.0.
51.2% had a parental history of T2DM, and those with a positive parental history were diagnosed six years earlier than those with a negative parental history (p < 0.001). A significant correlation between parental history and gestational diabetes mellitus (GDM) was observed (p < 0.001). Patients with a parental history reported better dietary adherence (p < 0.001). Binary logistic regression analysis revealed patients with positive parental history had significantly lower HbA (p = 0.003, OR = 0.748).
T2DM patients with a parental history showed significant association with early diabetes onset, GDM, better glycemic control, and dietary adherence.
糖尿病家族史是2型糖尿病（T2DM）的既定危险因素。关于斯里兰卡糖尿病家族史与T2DM患病率之间关联的数据有限。本研究旨在调查T2DM患者的糖尿病家族史患病率及其与发病年龄、血糖控制和自我报告的饮食依从性等因素的相关性。随着斯里兰卡T2DM发病率的上升，了解糖尿病家族史对诊断年龄和血糖控制的影响有助于进行有针对性的筛查和干预。
对500名在斯里兰卡南部首都加勒一家糖尿病诊所就诊的T2DM患者进行了一项横断面研究，该地区人口种族多样。招募过程采用方便抽样策略，并使用基于问卷的方法收集数据。所有收集的数据均使用SPSS V 版本25.0进行分析。
51.2%的患者有糖尿病家族史，有阳性家族史的患者比有阴性家族史的患者早6年被诊断出糖尿病（p < 0.001）。观察到糖尿病家族史与妊娠期糖尿病（GDM）之间存在显著相关性（p < 0.001）。有糖尿病家族史的患者报告饮食依从性更好（p < 0.001）。二元逻辑回归分析显示，有阳性家族史的患者糖化血红蛋白（HbA）显著更低（p = 0.003，OR = 0.748）。
有糖尿病家族史的T2DM患者与糖尿病早发、GDM、更好的血糖控制和饮食依从性显著相关。
