Taillefer R, Lambert R, Grégoire J, Essiambre R, Phaneuf D C
Service de médecine nucléaire, Hôtel-Dieu de Montréal, Québec.
Union Med Can. 1990 Nov-Dec;119(6):322, 324, 326-9.
99mTc-SESTAMIBI is a new myocardial perfusion agent used in the detection of atherosclerotic coronary artery disease. In the present study, myocardial scintiscanning (on treadmill) with 99mTc-SESTAMIBI and 201-Thallium were compared, and both were compared with coronary angiography. Some 130 consecutive patients were evaluated within an interval of a few weeks with scintiscans of both 99mTc-SESTAMIBI and 201-Thallium: 82 of them were also examined by coronary angiography. Segmental analysis of the two series of scans revealed some correlation in 89.2% of the segments, while correlation of the final diagnosis showed agreement in 92% of cases. Compared to coronary angiography, sensitivity in the detection of CAD was found to be 75.8% for 201-Thallium and 72.5% for 99mTc-SESTAMIBI. The authors conclude that 99mTc-SESTAMIBI is a promising myocardial perfusion agent which displays an excellent correlation with 201-Thallium.
99m锝-甲氧基异丁基异腈是一种用于检测动脉粥样硬化性冠状动脉疾病的新型心肌灌注剂。在本研究中，对99m锝-甲氧基异丁基异腈和铊-201的心肌闪烁扫描（在跑步机上）进行了比较，并将两者与冠状动脉造影进行了比较。在几周的时间间隔内，对约130例连续患者进行了99m锝-甲氧基异丁基异腈和铊-201的闪烁扫描评估：其中82例还接受了冠状动脉造影检查。对这两组扫描的节段分析显示，89.2%的节段存在一定相关性，而最终诊断的相关性在92%的病例中显示一致。与冠状动脉造影相比，铊-201检测冠心病的敏感性为75.8%，99m锝-甲氧基异丁基异腈为72.5%。作者得出结论，99m锝-甲氧基异丁基异腈是一种有前景的心肌灌注剂，与铊-201显示出极好的相关性。
