Université de Pau et des Pays de l'Adour/CNRS, Laboratoire de Chimie Analytique Bio-Inorganique et Environnement, UMR IPREM, Technopôle Hélioparc, France.
Anal Chim Acta. 2011 Apr 29;692(1-2):26-41. doi: 10.1016/j.aca.2011.02.052. Epub 2011 Mar 1.
The stakes concerning the characterisation of particles ranged in the size from 1 to 1000 nm, namely submicron particles, are today more and more important. Because of the variety of particles even inside a given sample in terms of dimension, mass, charge or chemical composition a characterisation as complete as possible is needed. The possibility of obtaining a multidimensional information by relevant analytical methods is then of the greatest interest. One very interesting strategy consists in using hyphenated techniques, which are intrinsically capable to provide rapidly and accurately such information. This paper summarises the different hyphenated techniques that can be used to characterise submicron particles and is focussed on their main applications to illustrate their current and potential uses. In order to have a relevant overview various on-line separation techniques are considered in a comparative way. In the same way various on-line detectors are then presented. Finally the concepts of multidetection and multidimensional analysis are discussed and their interest showed through different typical examples of hyphenated techniques illustrating submicron particle characterisation in fields of applications such as environmental and nanomaterial sciences.
对于尺寸在 1 至 1000nm 之间的颗粒（即亚微米颗粒）的特性描述，其重要性日益增加。由于在给定样品内颗粒的维度、质量、电荷或化学成分存在多样性，因此需要尽可能全面的特性描述。如果可以通过相关分析方法获得多维信息，那么这将具有最大的意义。一种非常有趣的策略是使用联用技术，该技术本质上能够快速且准确地提供此类信息。本文总结了可用于描述亚微米颗粒的不同联用技术，并重点介绍了它们的主要应用，以说明它们的当前和潜在用途。为了进行有意义的综述，本文以比较的方式考虑了各种在线分离技术，然后还介绍了各种在线检测器。最后，讨论了多维检测和多维分析的概念，并通过一些联用技术的典型实例说明了它们的应用，如环境科学和纳米材料科学等领域的亚微米颗粒特性描述，从而展示了它们的意义。
