Department of Dermatology, Rambam Medical Center and the Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, Haifa, Israel.
J Am Acad Dermatol. 2011 Jul;65(1):112-24. doi: 10.1016/j.jaad.2010.07.003. Epub 2011 Apr 17.
Cutaneous lymphoid hyperplasia (CLH) is generally classified according to clinicopathologic entities or put into broad spectrums of B-cell or T-cell predominance or co-dominance.
We sought to discern histologic features and immunohistochemical staining patterns in CLH that may form a basis for a histologic classification system.
We studied the clinical, histologic, immunophenotypical, and molecular characteristics of 24 consecutive patients with CLH.
The 24 cases were classified according to characteristic histologic features and immunophenotypical staining patterns as follows: presence of germinal center (GC) cell clusters forming well-defined lymphoid follicles (n = 10); presence of clusters of GC cell clusters not forming well-defined lymphoid follicles (n = 6); persistent arthropod assault type CLH (n = 1); CLH with a prominent histiocytic component (n = 4); and CLH without specific histologic and immunophenotypical features, that is, nonspecific mixed T-cell and B-cell CLH (n = 3). Most of the CLH cases did not demonstrate clonal T-cell receptor and/or immunoglobulin heavy chain gene rearrangements except for 3 cases in which the long-term follow-up was uneventful.
There were a limited number of cases in our study.
A classification based on characteristic histologic features and immunophenotypical staining patterns, along with pertinent clinical and molecular data, may enhance the diagnosis of CLH.
皮肤淋巴组织增生（CLH）通常根据临床病理实体进行分类，或归入 B 细胞或 T 细胞优势或共同优势的广泛谱。
我们试图发现 CLH 中的组织学特征和免疫组织化学染色模式，这些特征和模式可能为组织学分类系统提供基础。
我们研究了 24 例连续 CLH 患者的临床、组织学、免疫表型和分子特征。
根据特征性组织学特征和免疫表型染色模式，这 24 例病例被分类为以下几种类型：存在形成明确淋巴滤泡的生发中心（GC）细胞簇（n = 10）；存在不形成明确淋巴滤泡的 GC 细胞簇（n = 6）；持续存在节肢动物侵袭型 CLH（n = 1）；具有突出组织细胞成分的 CLH（n = 4）；以及没有特定组织学和免疫表型特征的 CLH，即非特异性混合 T 细胞和 B 细胞 CLH（n = 3）。除了 3 例长期随访无事件的病例外，大多数 CLH 病例未显示克隆 T 细胞受体和/或免疫球蛋白重链基因重排。
我们的研究中病例数量有限。
基于特征性组织学特征和免疫表型染色模式，以及相关的临床和分子数据的分类，可能会增强 CLH 的诊断。
