Raess Philipp W, Bagg Adam
Department of Pathology and Laboratory Medicine, University of Pennsylvania, 7.103 Founders Pavilion, 3400 Spruce Street, Philadelphia, PA 19104-4283, USA.
Patholog Res Int. 2012;2012:913523. doi: 10.1155/2012/913523. Epub 2012 Nov 19.
Primary cutaneous lymphomas can be difficult to be distinguished from reactive mimics, even when integrating histologic, immunophenotypic, and clinical findings. Molecular studies, especially PCR-based antigen receptor gene rearrangement (ARGR) analysis, are frequently useful ancillary studies in the evaluation of cutaneous lymphoproliferations. The biologic basis of ARGR studies is discussed, as well as a comparison of various current protocols. The pitfalls and limitations of ARGR analysis are also highlighted. Recent advances in the understanding of the molecular pathogenesis of various cutaneous lymphomas are discussed. Some of these nascent discoveries may lead to the development of diagnostically useful molecular assays.
原发性皮肤淋巴瘤即使结合组织学、免疫表型和临床发现，也可能难以与反应性模仿病变相区分。分子研究，尤其是基于聚合酶链反应（PCR）的抗原受体基因重排（ARGR）分析，在评估皮肤淋巴增殖性疾病时常常是有用的辅助研究。本文讨论了ARGR研究的生物学基础，以及对各种当前方案的比较。还强调了ARGR分析的陷阱和局限性。讨论了对各种皮肤淋巴瘤分子发病机制理解的最新进展。其中一些新发现可能会导致开发出具有诊断价值的分子检测方法。
