Ohtsuka Y, Kobayashi K, Hirano T, Furukawa S, Nagano S, Takahashi T
First Department of Internal Medicine, Showa University School of Medicine, Tokyo, Japan.
Gerontology. 1990;36(5-6):268-75. doi: 10.1159/000213211.
Sera from the elderly, but not young, inhibited markedly interleukin 2 (IL-2)-dependent proliferation of cloned T cells. Sera of aged humans contained high levels of triglyceride, cholesterol, very low density lipoproteins (VLDL) and low density lipoproteins (LDL). VLDL and LDL inhibited the proliferation in a dose-related manner. The inhibition correlated with levels of serum VLDL and LDL. These results suggest that lipoproteins may act as a regulator of IL-2-dependent proliferation and that disturbance of lipid and lipoprotein metabolism may be partially responsible for diminished immune responses in the elderly.
老年人而非年轻人的血清能显著抑制克隆T细胞依赖白细胞介素2（IL-2）的增殖。老年人的血清中含有高水平的甘油三酯、胆固醇、极低密度脂蛋白（VLDL）和低密度脂蛋白（LDL）。VLDL和LDL以剂量相关的方式抑制增殖。这种抑制作用与血清VLDL和LDL的水平相关。这些结果表明脂蛋白可能作为IL-2依赖增殖的调节剂，并且脂质和脂蛋白代谢紊乱可能部分导致老年人免疫反应减弱。
