使用手性冠醚固定相直接分离氨基酸对映体。应用于2-氨基-ω-膦酰基链烷酸。
Direct separation of amino acid enantiomers using a chiral crown ether stationary phase. Application to 2-amino-omega-phosphonoalkanoic acids.
作者信息
Udvarhelyi P M, Sunter D C, Watkins J C
机构信息
Department of Pharmacology, School of Medical Sciences, University of Bristol, U.K.
出版信息
J Chromatogr. 1990 Oct 19;519(1):69-74. doi: 10.1016/0021-9673(90)85135-i.
PMID:2150201
Abstract
The resolution of a series of 2-amino-omega-phosphonoalkanoic acid enantiomers using a crown ether chiral stationary phase is described. The method is applicable to other primary amino acid and shows some advantages over chiral derivatization with fluorometric detection. Optical isomers of under 0.5% may be quantified.
摘要
描述了使用冠醚手性固定相拆分一系列2-氨基-ω-膦酰基链烷酸对映体的方法。该方法适用于其他伯氨基酸，并且与荧光检测的手性衍生化相比具有一些优势。含量低于0.5%的光学异构体可以被定量。
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