School of Health and Social Care, University of Reading, Berkshire, UK.
Age Ageing. 2011 Jul;40(4):430-6. doi: 10.1093/ageing/afr016. Epub 2011 Apr 18.
randomised controlled trials (RCTs) of falls prevention conducted in institutional settings have recently been systematically reviewed.
to supplement this review by analysing older people's participation in the trials and engagement with the interventions.
review of the 41 RCTs included in the Cochrane systematic review of falls prevention interventions.
hospitals and nursing care facilities.
adults aged/mean age of 65+.
calculated aggregate data on recruitment (inclusion into the trial), attrition at 12-month follow-up (loss of participants from the trial), adherence (to intervention protocol), and whether adherence moderated the effect of interventions on trial outcomes.
the median inclusion rate was 48.5% (38.9-84.5%). At 12 months the median attrition rate was 10.4% (3.9-12.3%, n = 10) or with the inclusion of mortality 16.2% (9.5-17.1%, n = 11). Adherence was high for exercise that was individually targeted (e.g. 89% physical therapy) and group based (72-88%) and for medication interventions (68-88%). For multifactorial interventions, adherence ranged from 11% for attending 60+/88 of exercise classes to 93% for use/repairs of aids. Adherence as a moderator of treatment effectiveness was tested in nursing care facilities (n = 6) and positively identified in three studies for medication and multifactorial interventions.
using median rates for recruitment (50%), attrition (15%) and adherence (80%), by 12 months, it is estimated that on average only a third of nursing care facility residents are likely to be adhering to falls prevention interventions.
最近对机构环境中进行的跌倒预防随机对照试验(RCT)进行了系统评价。
通过分析老年人参与试验和对干预措施的参与情况,对该综述进行补充。
对 Cochrane 跌倒预防干预措施系统评价中纳入的 41 项 RCT 进行综述。
医院和护理院。
年龄/平均年龄为 65 岁以上的成年人。
计算了关于招募(纳入试验)、12 个月随访时的流失率(从试验中损失的参与者)、依从性(干预方案)以及依从性是否调节干预措施对试验结果的影响的综合数据。
中位数纳入率为 48.5%(38.9-84.5%)。在 12 个月时,中位数流失率为 10.4%(3.9-12.3%,n=10)或包括死亡率为 16.2%(9.5-17.1%,n=11)。针对个体针对性的锻炼(例如,89%的物理治疗)和小组基础锻炼(72-88%)以及药物干预措施(68-88%),其依从性较高。对于多因素干预措施,依从性范围从参加 60+/88 节锻炼课程的 11%到使用/修复辅助工具的 93%。在护理院(n=6)中,作为治疗效果的调节因素,对药物和多因素干预措施进行了测试,并在三项研究中得到了积极的验证。
使用招募(50%)、流失(15%)和依从性(80%)的中位数率,到 12 个月时,估计护理院居民中只有三分之一可能会坚持预防跌倒的干预措施。