单纯疱疹病毒 1 型基因组的核传递机制。

Nuclear delivery mechanism of herpes simplex virus type 1 genome.

机构信息

Institute of Physiology II, University of Münster, Robert-Koch-Str. 27b, 48147 Münster, Germany.

出版信息

J Mol Recognit. 2011 May-Jun;24(3):414-21. doi: 10.1002/jmr.1120.

Abstract

Herpes simplex virus type 1 (HSV-1) is a widespread human pathogen infecting more than 80% of the population worldwide. Its replication involves an essential, poorly understood multistep process, referred to as uncoating. Uncoating steps are as follows: (1) The incoming capsid pinpoints the nuclear pore complex (NPC). (2) It opens up at the NPC and releases the highly pressurized viral genome. (3) The viral genome translocates through the NPC. In the present review, we highlight recent advances in this field and propose mechanisms underlying the individual steps of uncoating. We presume that the incoming HSV-1 capsid pinpoints the NPC by hydrophobic interactions and opens up upon binding to NPC proteins. Genome translocation is initially pressure-driven.

摘要

单纯疱疹病毒 1 型（HSV-1）是一种广泛存在的人类病原体，感染了全球超过 80%的人口。它的复制涉及一个基本但尚未被充分理解的多步骤过程，称为脱壳。脱壳步骤如下：（1）进入的衣壳定点核孔复合体（NPC）。（2）在 NPC 处打开并释放出高压的病毒基因组。（3）病毒基因组通过 NPC 迁移。在本综述中，我们强调了该领域的最新进展，并提出了脱壳各个步骤的潜在机制。我们推测，进入的 HSV-1 衣壳通过疏水相互作用定点 NPC，并在与 NPC 蛋白结合后打开。基因组迁移最初是由压力驱动的。