Cui Yuxi, Wang Mingshu, Cheng Anchun, Zhang Wei, Yang Qiao, Tian Bin, Ou Xumin, Huang Juan, Wu Ying, Zhang Shaqiu, Sun Di, He Yu, Zhao Xinxin, Wu Zhen, Zhu Dekang, Jia Renyong, Chen Shun, Liu Mafeng
Engineering Research Center of Southwest Animal Disease Prevention and Control Technology, Ministry of Education of the People's Republic of China, Chengdu, China.
Key Laboratory of Animal Disease and Human Health of Sichuan Province, Chengdu, China.
Front Microbiol. 2024 Jul 2;15:1431672. doi: 10.3389/fmicb.2024.1431672. eCollection 2024.
Alphaherpesvirus is a widespread pathogen that causes diverse diseases in humans and animals and can severely damage host health. Alphaherpesvirus particles comprise a DNA core, capsid, tegument and envelope; the tegument is located between the nuclear capsid and envelope. According to biochemical and proteomic analyses of alphaherpesvirus particles, the tegument contains at least 24 viral proteins and plays an important role in the alphaherpesvirus life cycle. This article reviews the important role of tegument proteins and their interactions during the viral life cycle to provide a reference and inspiration for understanding alphaherpesvirus infection pathogenesis and identifying new antiviral strategies.
α疱疹病毒是一种广泛传播的病原体，可导致人类和动物患上多种疾病，并能严重损害宿主健康。α疱疹病毒颗粒由DNA核心、衣壳、被膜和包膜组成；被膜位于核衣壳和包膜之间。根据对α疱疹病毒颗粒的生化和蛋白质组学分析，被膜至少包含24种病毒蛋白，并且在α疱疹病毒的生命周期中发挥着重要作用。本文综述了被膜蛋白在病毒生命周期中的重要作用及其相互作用，为理解α疱疹病毒感染发病机制和确定新的抗病毒策略提供参考和启示。
