Department of Chemistry, University of Toronto, Toronto, ON M5S3H6, Canada.
Macromol Biosci. 2011 Jul 7;11(7):889-96. doi: 10.1002/mabi.201100045. Epub 2011 Apr 19.
A microfluidic strategy for the encapsulation and stimulus-responsive release of molecules with distinct polarities from the interior of microgels is reported. The approach relies on (i) the generation of a primary O/W emulsion by the ultrasonication method, (ii) MF emulsification of the primary emulsion, and (iii) photopolymerization of the monomer present in the aqueous phase of the droplets, thereby transforming them into microgels. Non-polar molecules are dissolved in oil droplets embedded in the microgels. Polar molecules are physically associated with the hydrogel network. Upon heating, the microgels contract and release polar and non-polar cargo molecules. The approach paves the way for stimuli-responsive vehicles for multiple drug delivery.
报道了一种从微凝胶内部封装和响应刺激释放具有不同极性分子的微流控策略。该方法依赖于：(i) 通过超声方法生成初级 O/W 乳液，(ii) 对初级乳液进行 MF 乳化，以及 (iii) 液滴水相中的单体的光聚合，从而将其转化为微凝胶。非极性分子溶解在嵌入微凝胶中的油滴中。极性分子与水凝胶网络物理结合。加热时，微凝胶收缩并释放极性和非极性货物分子。该方法为多种药物输送的响应性载体铺平了道路。
