ACS Appl Mater Interfaces. 2010 Dec;2(12):3411-6. doi: 10.1021/am100860b. Epub 2010 Nov 17.
A microfluidic melt emulsification method for encapsulation and release of actives is presented. Using a water-in-oil-in-water (W-O-W) double emulsion template, solid capsules can be formed by freezing the middle shell phase. Actives encapsulated inside the solid shell can be controllably and rapidly released by applying a temperature trigger to melt the shell. The choice of the shell materials can be chosen to accommodate the storage and release temperatures specific to the applications. In addition, we have also demonstrated the same concept to encapsulate multiple actives in multicompartment capsules, which are promising as multifunctional capsules and microreactors.
本文提出了一种用于活性物质包封和释放的微流熔融乳化方法。使用油包水包油（W-O-W）双重乳液模板，通过冷冻中间壳相可以形成固体胶囊。通过施加温度触发来熔化壳，可以控制和快速释放封装在固体壳内的活性物质。可以选择壳材料以适应特定于应用的存储和释放温度。此外，我们还展示了相同的概念，用于封装多隔室胶囊中的多种活性物质，作为多功能胶囊和微反应器具有广阔的应用前景。
