4th Department of Obstetrics and Gynaecology, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Gynecol Endocrinol. 2011 Dec;27(12):1070-3. doi: 10.3109/09513590.2011.569793. Epub 2011 Apr 19.
The aim of the present study was to investigate whether normal pregnancy represents a complex state of oxidative stress, inflammation and insulin resistance.
One hundred and six pregnant women, between 24th and 28th week of pregnancy (age 27.9 ± 0.4 years) (study group) and one hundred and six age-matched, healthy, non-pregnant women (control group) participated in the study. Serum levels of glucose, insulin, adiponectin, oxidized LDL (oxLDL) and lipid parameters, i.e. total cholesterol (TC), triglycerides (TG), HDL and LDL, were determined. Body mass index (BMI) and QUantitative Insulin sensitivity ChecK Index (QUICKI) were also calculated.
Pregnant women presented higher BMI values, insulin and oxLDL serum levels and lower glucose serum levels than controls. Serum levels of lipids (TC, TG, LDL and HDL) were higher in pregnant women. There was a significant positive correlation of oxLDL to adiponectin (p < 0.01) in the study group, but not in the controls, and no other significant correlation with any of the other parameters, in either of groups.
Pregnancy is a state of insulin resistance, oxidative stress and pro-atherogenic hyperlipidemia. Adiponectin may, though, have cardioprotective role in pregnant women.
本研究旨在探讨正常妊娠是否代表一种复杂的氧化应激、炎症和胰岛素抵抗状态。
106 名孕妇（年龄 27.9 ± 0.4 岁）于妊娠 24 至 28 周（研究组），以及 106 名年龄匹配的健康未妊娠妇女（对照组）参与了本研究。测定了血清葡萄糖、胰岛素、脂联素、氧化型 LDL（oxLDL）和血脂参数（总胆固醇 [TC]、甘油三酯 [TG]、高密度脂蛋白 [HDL]和低密度脂蛋白 [LDL]）水平。还计算了体重指数（BMI）和 QUickI。
与对照组相比，孕妇 BMI 值、胰岛素和 oxLDL 血清水平更高，而血糖水平更低。孕妇的血脂（TC、TG、LDL 和 HDL）水平更高。研究组 oxLDL 与脂联素呈显著正相关（p < 0.01），但对照组无此相关性，且两组间无其他与任何其他参数的显著相关性。
妊娠是一种胰岛素抵抗、氧化应激和促动脉粥样硬化性血脂异常状态。脂联素可能对孕妇具有心脏保护作用。
