Clinic of Obstetrics and Gynaecology, 424 Military Hospital, 54629 Thessaloniki, Greece.
Eur J Endocrinol. 2011 Apr;164(4):579-83. doi: 10.1530/EJE-10-1020. Epub 2011 Jan 31.
Pregnancy represents a state of insulin resistance (IR). Vaspin (SERPINA12) is a novel insulin-sensitizing adipokine that might be implicated in endogenous glucose regulation. However, its role in pregnancy and its circulating levels have not been adequately studied. We aimed to evaluate serum vaspin levels in pregnancy and their correlation with known markers of IR.
A group of 106 women (age 27.9±0.4 years) at the 24-30th week of gestation (pregnancy group) and another 106 age-matched healthy non-pregnant controls (control group) were included in the study.
Serum glucose, insulin, vaspin, adiponectin, and lipid parameters were measured. The quantitative insulin sensitivity check index (QUICKI) was used as an insulin sensitivity index.
Pregnant women had significantly higher body mass index (BMI), lipids, and serum insulin and lower serum glucose and vaspin levels than controls. Vaspin was positively correlated to adiponectin in both groups (P<0.001 and P<0.004 respectively) but was not correlated to BMI, serum insulin levels, or the QUICKI index in either group. Furthermore, vaspin was negatively correlated to lipid parameters (total cholesterol, triglycerides, and low-density lipoproteins) in the pregnant but not in the non-pregnant women.
Vaspin cannot serve as a marker of IR in either pregnant or non-pregnant women, although it is significantly correlated with adiponectin. On the other hand, vaspin might be useful as a surrogate marker of lipid metabolism in pregnancy if confirmed by subsequent studies.
妊娠是一种胰岛素抵抗（IR）状态。 Vaspin（SERPINA12）是一种新的胰岛素增敏脂肪因子，可能与内源性葡萄糖调节有关。 然而，其在妊娠中的作用及其循环水平尚未得到充分研究。 我们旨在评估妊娠期间血清 vaspin 水平及其与已知 IR 标志物的相关性。
本研究纳入了 106 名妊娠 24-30 周的孕妇（妊娠组）和 106 名年龄匹配的健康未怀孕对照者（对照组）。
测量血清葡萄糖、胰岛素、vaspin、脂联素和血脂参数。 使用定量胰岛素敏感性检查指数（QUICKI）作为胰岛素敏感性指数。
与对照组相比，孕妇的体重指数（BMI）、血脂、血清胰岛素水平显著升高，而血清葡萄糖和 vaspin 水平显著降低。 在两组中，vaspin 均与脂联素呈正相关（分别为 P<0.001 和 P<0.004），但与 BMI、血清胰岛素水平或两组中的 QUICKI 指数均无相关性。 此外，在妊娠妇女中，vaspin 与血脂参数（总胆固醇、甘油三酯和低密度脂蛋白）呈负相关，但在非妊娠妇女中则无相关性。
尽管 vaspin 与脂联素显著相关，但不能作为妊娠或非妊娠妇女 IR 的标志物。 另一方面，如果后续研究证实，vaspin 可能是妊娠期间脂代谢的有用替代标志物。
