Brown H D, Chattopadhyay S K
Department of Biochemistry, NJAES, Rutgers University, New Brunswick 08903.
Cancer Biochem Biophys. 1990 Nov;11(4):317-20.
Presence of chlorpromazine, a non-active-site inhibitor of Na(+)-K(+)-ATPase catalytic activity, in a reaction system exposed to 9.14 GHz CW radiation, resulted in approximately 23% inhibition. This effect was temperature-independent within the normal range for this protein. A low-level microwave field also inhibited the enzyme catalytic rate. Loci of chlorpromazine inhibition and of low-level microwave inhibition appear to be distinct and non-interactive under the conditions of this study. Use of enzyme reaction systems as models for microwave causation of leukemia and the possible involvement of pharmacological agents, such as ouabain and chlorpromazine, in this process has been considered.
在暴露于9.14 GHz连续波辐射的反应体系中，存在氯丙嗪（一种Na(+)-K(+)-ATP酶催化活性的非活性位点抑制剂）会导致约23%的抑制率。在该蛋白质的正常温度范围内，这种效应与温度无关。低水平微波场也会抑制酶的催化速率。在本研究条件下，氯丙嗪抑制位点和低水平微波抑制位点似乎是不同的且无相互作用。已考虑将酶反应体系用作微波引发白血病的模型，以及毒毛花苷和氯丙嗪等药物制剂在此过程中可能的参与情况。
