Bobek P, Ginter E, Jurcovicová M, Babala J, Ozdín L, Cerven J
Institute of Human Nutrition, Bratislava.
Physiol Bohemoslov. 1990;39(4):361-9.
Golden hamsters with alimentary hyperlipoproteinaemia (fed on a diet in which 44% of the energy was accounted for by fats, 52 mg cholesterol (CH)/100 g) were given apple pulp (10% of the diet) for six months. From the end of the first month up to the end of the experiment, elevation of serum CH, triacylglycerol (TG) and phospholipid (PL) levels and CH and TG accumulation in the liver were effectively inhibited. At the close of the experiment, hyperlipoproteinaemia was characterized by an increase in the amount of very low density lipoproteins (VLDL), which carried 60-80% of all circulating lipids, accounted for over 70% of the total lipoprotein pool and transported almost 60% of the serum CH (high density lipoproteins--HDL--only 16%). The apple diet markedly reduced (by 50-80%) the amount of all lipids in the lipoproteins within density limits of 1,006-1,063 kg/m3 and lowered the total lipid concentration in these density classes and in the lipoprotein pool as a whole (by 50%). The proportion of the individual lipoprotein classes in the lipoprotein pool was not significantly affected. The apple diet did not affect either the chemical composition of HDL or their participation in the lipoprotein pool, but raised the proportion of serum CH transported in this lipoprotein class. Neither the lipoprotein lipase activity of the adipose tissue nor lecithin:cholesterol acyltransferase activity were influenced by the apple diet.
给患有营养性高脂蛋白血症的金黄仓鼠（喂食一种脂肪提供44%能量、胆固醇含量为52毫克/100克的饮食）喂食苹果果肉（占饮食的10%），持续六个月。从第一个月末到实验结束，血清胆固醇（CH）、三酰甘油（TG）和磷脂（PL）水平的升高以及肝脏中CH和TG的积累均受到有效抑制。在实验结束时，高脂蛋白血症的特征是极低密度脂蛋白（VLDL）数量增加，VLDL携带了所有循环脂质的60 - 80%，占总脂蛋白池的70%以上，并运输了近60%的血清CH（高密度脂蛋白 - HDL - 仅占16%）。苹果饮食显著降低了密度在1,006 - 1,063千克/立方米范围内的脂蛋白中所有脂质的含量（降低了50 - 80%），并降低了这些密度类别的脂蛋白以及整个脂蛋白池中总脂质浓度（降低了50%）。脂蛋白池中各个脂蛋白类别的比例未受到显著影响。苹果饮食既未影响HDL的化学组成，也未影响其在脂蛋白池中的参与情况，但提高了该脂蛋白类别运输的血清CH的比例。苹果饮食对脂肪组织的脂蛋白脂肪酶活性和卵磷脂：胆固醇酰基转移酶活性均无影响。
