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[半月板的组织病理学评估]

[Histopathological evaluation of the meniscus].

作者信息

Fisseler-Eckhoff A, Müller K-M

机构信息

Institut für Pathologie und Zytologie, Dr. Horst Schmidt Kliniken GmbH Wiesbaden, Ludwig-Erhard-Str. 100, 65199, Wiesbaden.

出版信息

Pathologe. 2011 May;32(3):220-7. doi: 10.1007/s00292-011-1420-8.

DOI:10.1007/s00292-011-1420-8
PMID:21505874
Abstract

Menisci fulfill many functions within the complex biomechanics of the knee joint. In the case of meniscus lesions, sparing arthroscopic resection and surgical refixation are the treatments of choice. In terms of diagnosis, this means in general that histopathologic diagnostics are carried out on detached meniscus fragments of between 5 mm and 2 cm in size. A good knowledge of physiologically possible cellular and fibrous histological meniscus damage, as opposed to nonphysiological change regarded as normal with respect to age, is essential for diagnostic meniscus evaluation. The clinician expects clear statements from the pathologist regarding the severity of previous or secondary degenerative meniscus damage, the age and type of traumatic tears, and an appraisal of the relationship between trauma and meniscus damage from an insurance point of view. Close cooperation between the clinician and the pathologist allows for a fast and unambiguous correlation of anamnesis, the clinical picture, and morphological reporting such that problematic insurance cases can be clarified quickly.

摘要

半月板在膝关节复杂的生物力学中发挥着多种功能。对于半月板损伤,保留性关节镜下切除术和手术修复是首选治疗方法。在诊断方面,这通常意味着对大小在5毫米至2厘米之间的分离半月板碎片进行组织病理学诊断。了解生理上可能出现的细胞和纤维组织学半月板损伤,与被视为正常年龄相关的非生理性变化相对,对于半月板诊断评估至关重要。临床医生期望病理学家就先前或继发性退行性半月板损伤的严重程度、创伤性撕裂的年龄和类型,以及从保险角度对创伤与半月板损伤之间关系作出明确说明。临床医生和病理学家之间的密切合作能够快速且明确地关联病史、临床表现和形态学报告,从而迅速澄清有问题的保险案例。

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[MALDI mass spectrometry of the meniscus. Objectification of morphological findings].[半月板的基质辅助激光解吸电离质谱分析。形态学发现的客观化]
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本文引用的文献

1
[Meniscal degeneration score and NITEGE expression : immunohistochemical detection of NITEGE in advanced meniscal degeneration].[半月板退变评分与NITEGE表达:晚期半月板退变中NITEGE的免疫组化检测]
Orthopade. 2010 May;39(5):475-85. doi: 10.1007/s00132-010-1606-4.
2
[Histopathological meniscus diagnostic].[组织病理学半月板诊断]
Orthopade. 2009 Jun;38(6):539-45. doi: 10.1007/s00132-008-1401-7.
3
Knee joint changes after meniscectomy.半月板切除术后的膝关节变化。
J Bone Joint Surg Br. 1948 Nov;30B(4):664-70.
4
Evaluation of postoperative menisci with MR arthrography and routine conventional MRI.采用磁共振关节造影和常规传统磁共振成像评估术后半月板。
Clin Imaging. 2008 May-Jun;32(3):212-9. doi: 10.1016/j.clinimag.2007.09.008.
5
Involvement of the p38 MAPK-NF-kappaB signal transduction pathway and COX-2 in the pathobiology of meniscus degeneration in humans.p38丝裂原活化蛋白激酶-核因子κB信号转导通路及环氧化酶-2在人类半月板退变病理生物学中的作用
Mol Med. 2008 Mar-Apr;14(3-4):160-6. doi: 10.2119/2007-00138.Papachristou.
6
The sheep as a knee osteoarthritis model: early cartilage changes after meniscus injury and repair.绵羊作为膝关节骨关节炎模型:半月板损伤与修复后的早期软骨变化
Lab Anim. 2007 Oct;41(4):420-31. doi: 10.1258/002367707782314265.
7
Physical examination tests for assessing a torn meniscus in the knee: a systematic review with meta-analysis.用于评估膝关节半月板撕裂的体格检查测试:一项荟萃分析的系统评价
J Orthop Sports Phys Ther. 2007 Sep;37(9):541-50. doi: 10.2519/jospt.2007.2560.
8
Clinical and arthroscopic features of meniscal tears and a search for the role of infection in histologically confirmed meniscal mucoid degeneration.半月板撕裂的临床及关节镜特征以及对感染在组织学确诊的半月板黏液样变性中作用的探究。
Knee Surg Sports Traumatol Arthrosc. 2004 Jul;12(4):294-9. doi: 10.1007/s00167-003-0412-5. Epub 2003 Sep 18.
9
Immunohistochemical localization of the small proteoglycans decorin and biglycan in human intervertebral discs.小蛋白聚糖核心蛋白聚糖和双糖链蛋白聚糖在人椎间盘内的免疫组织化学定位
Cell Tissue Res. 1997 Jul;289(1):185-90. doi: 10.1007/s004410050864.
10
[Meniscus lesions].[半月板损伤]
Orthopade. 1997 Feb;26(2):191-208. doi: 10.1007/s001320050085.