Department of Surgical and Perioperative Sciences, Sports Medicine, Umeå University, 90185 Umeå, Sweden.
Osteoporos Int. 2012 Mar;23(3):963-70. doi: 10.1007/s00198-011-1631-0. Epub 2011 Apr 20.
The association between bone mineral density (BMD) and myocardial infarction (MI) was investigated in 6,872 men and women. For both men and women, lower BMD in the femoral neck and hip was associated with increased risk of MI largely independent of smoking, hypertension, hypertriglyceridemia, and diabetes.
The relationship between BMD and cardiovascular disease is not completely understood. The objective of this prospective study was to investigate the risk of MI in relation to bone mineral density and to determine if cardiovascular risk factors could explain this association.
Dual energy X-ray absorptiometry was performed in 5,490 women and 1,382 men to determine total hip and femoral neck BMD (in grams per square centimeters) and estimate femoral neck volumetric BMD (in grams per cubic centimeters). During a mean follow-up time of 5.7 years, 117 women and 79 men suffered an initial MI.
After adjustment for age and BMI, lower BMD of the femoral neck and total hip was associated with increased risk of MI for both women [hazard ratio (HR) = 1.33, 95% confidence interval (CI) 1.08-1.66 per standard deviation (SD) decrease in femoral neck BMD] and men (HR = 1.74, 95% CI 1.34-2.28 per SD decrease in total hip BMD). After additional adjustment for smoking, hypertension, hypertriglyceridemia, and diabetes, the associations were slightly attenuated in men (HR = 1.42-1.88 in the age and BMI-adjusted model versus 1.33-1.77 in the fully adjusted model) while similar attenuations were seen in women (HR = 1.06-1.25 versus 1.05-1.22).
Lower BMD was associated with an increase in MI risk for both men and women. Women had consistently lower HRs compared to men in all models. Adjusting for smoking, hypertension, hypertriglyceridemia, and diabetes did not distinctively weaken these associations.
研究了 6872 名男性和女性的骨密度（BMD）与心肌梗死（MI）之间的关系。对于男性和女性，股骨颈和髋部的较低 BMD 与 MI 风险的增加密切相关，且主要与吸烟、高血压、高三酰甘油血症和糖尿病无关。
对 5490 名女性和 1382 名男性进行双能 X 线吸收法检查，以确定总髋部和股骨颈 BMD（每平方厘米克数），并估计股骨颈容积 BMD（每立方厘米克数）。在平均 5.7 年的随访期间，117 名女性和 79 名男性首次发生 MI。
在校正年龄和 BMI 后，女性的股骨颈和总髋部的 BMD 较低与 MI 风险增加相关[风险比（HR）=1.33，95%置信区间（CI）1.08-1.66 每标准偏差（SD）股骨颈 BMD 降低]，男性（HR = 1.74，95%CI 1.34-2.28，每 SD 总髋 BMD 降低）。在校正吸烟、高血压、高三酰甘油血症和糖尿病后，男性的相关性略有减弱（在年龄和 BMI 调整模型中 HR = 1.42-1.88，而在完全调整模型中 HR = 1.33-1.77），而女性也出现了类似的减弱（HR = 1.06-1.25，而 HR = 1.05-1.22）。
较低的 BMD 与男性和女性的 MI 风险增加相关。在所有模型中，女性的 HR 均低于男性。调整吸烟、高血压、高三酰甘油血症和糖尿病并没有明显削弱这些关联。
