Bone Metabolism Unit. Department of Internal Medicine, Hospital Universitario Marqués de Valdecilla, University of Cantabria, RETICEF, Santander, Spain.
Endocr J. 2010;57(1):51-60. doi: 10.1507/endocrj.k09e-228. Epub 2009 Oct 23.
There is growing evidence of a link between lipid and bone metabolism, although data on this association in European men are scarce. This cross-sectional study from a community-based prospective cohort aims to explore the association of serum lipids with different aspects of bone metabolism in Spanish men. Demographic and anthropometric measurements, biochemical parameters including serum lipids, bone remodelling markers and calciotropic hormones, bone mineral density (BMD) assessed by dual X-ray absorptiometry and heel quantitative ultrasound, and prevalent vertebral and non-vertebral fractures, were evaluated in 289 men. Calciotropic hormones or bone markers were not associated with serum lipids. Serum total (TC) and LDL cholesterol, as well as LDL/HDL ratio were positively correlated to BMD at lumbar spine and hip. No significant correlation was noted for triglycerides or HDL. We observed a positive association between triglycerides, LDL/HDL ratio and BUA, and between TC/HDL ratio and both, QUI and BUA. BMD at the femoral neck and total hip was significantly higher in men with hypercholesterolemia after controlling for all the covariates (p=0.007). We did not observe any association between serum lipids and prevalent vertebral fractures. However, we found that TC (p=0.03) and LDL (p=0.04) were lower in subjects with non-vertebral fractures. In conclusion, we have found that a more unfavorable lipid profile (mainly higher LDL-C levels) is associated with higher BMD at lumbar spine and hip in Spanish men. Moreover, we did not observe any association between hypercholesterolemia and prevalent vertebral fractures, but we found lower serum TC and LDL-C levels in men with prevalent non-vertebral fractures.
越来越多的证据表明脂质和骨骼代谢之间存在关联，尽管欧洲男性的数据对此关联很少。这项基于社区的前瞻性队列的横断面研究旨在探索西班牙男性的血清脂质与骨骼代谢不同方面之间的关系。对 289 名男性进行了人口统计学和人体测量学测量、生化参数（包括血清脂质、骨重塑标志物和钙调节激素）、骨矿物质密度（BMD）评估（双能 X 射线吸收法和脚跟定量超声）以及椎体和非椎体骨折的发生率。钙调节激素或骨标志物与血清脂质无关。血清总胆固醇（TC）和 LDL 胆固醇以及 LDL/HDL 比值与腰椎和髋部的 BMD 呈正相关。甘油三酯或 HDL 与 BMD 无显著相关性。我们观察到甘油三酯、LDL/HDL 比值与 BUA 之间以及 TC/HDL 比值与 QUI 和 BUA 之间呈正相关。在校正所有协变量后，股骨颈和全髋关节的 BMD 在高胆固醇血症男性中显著升高（p=0.007）。我们没有观察到血清脂质与椎体骨折之间存在任何关联。然而，我们发现患有非椎体骨折的患者的 TC（p=0.03）和 LDL（p=0.04）较低。总之，我们发现更不利的脂质谱（主要是更高的 LDL-C 水平）与西班牙男性腰椎和髋部的 BMD 更高有关。此外，我们没有观察到高胆固醇血症与椎体骨折之间存在任何关联，但我们发现患有非椎体骨折的男性的血清 TC 和 LDL-C 水平较低。
