Burmistrova A L, Ebert L Ia
Biull Eksp Biol Med. 1990 Nov;110(11):517-9.
The results of studies of functional activity of lymphocyte subpopulations: theophylline-sensitive (thphs-1) and theophylline-resistant (thphr-1), separated from peripheral blood of healthy people and patients with nonspecific ulcerative colitis (NUC) are represented in this paper. The evaluation of the separated subpopulations was performed by local xenogeneic graft-VS-host reaction, study of distribution of nonspecific esterase in cells and determination of relative amount of Fc gamma-R positive lymphocytes among thphs-1 and thphr-1. It was established that lymphocytes of patients with NUC had an alternative form of action on development of xenogeneic graft-VS-host reaction in contrast with cells of donors, that is inhibited the reaction. Among thphr-1 patients with NUC the amount of EC gamma-R cells and cells with diffuse distribution of enzyme with small degree activity was positively increased.
本文展示了从健康人和非特异性溃疡性结肠炎（NUC）患者外周血中分离出的淋巴细胞亚群（茶碱敏感型（thphs - 1）和茶碱抵抗型（thphr - 1））功能活性的研究结果。通过局部异种移植物抗宿主反应、细胞中非特异性酯酶分布的研究以及thphs - 1和thphr - 1中Fcγ - R阳性淋巴细胞相对数量的测定，对分离出的亚群进行了评估。结果表明，与供体细胞相比，NUC患者的淋巴细胞对异种移植物抗宿主反应的发展具有另一种作用形式，即抑制该反应。在NUC患者的thphr - 1中，ECγ - R细胞和酶活性程度小且呈弥漫性分布的细胞数量呈正向增加。
