Legon'kova L F, Bushma M I, Lukienko P I
Biull Eksp Biol Med. 1990 Dec;110(12):633-5.
The nicotinamide administration to rats (50 mg/kg, subcutaneously, over 5 days) increased the concentration of liver cytochrome b5, the activities of cytosol and microsomal glutathione S-transferase, UDP-glucuronosyltransferase and urinary excretion of bound glucuronic acid by 26.7, 33.1, 33.3, 53.0 and 31.0%, respectively. The chloral hydrate-induced sleep time in mice was reduced by 65%. Under similar experimental conditions the administration of equimolar amounts of diethylamide of nicotinic acid (75 mg/kg) exerted a more pronounced enzyme-stimulating effect. The cytochrome P-450 concentration, the activities of cytosol and microsomal glutathione S-transferase, UDP-glucuronosyltransferase as well as the sulphobromophthalein elimination from blood plasma and urinary excretion of bound glucuronic acid were increased by 37.0, 33.1, 54.6, 80.5, 24.5 and 49.0%, whereas the chloral hydrate-induced sleep time decreased by 75%. The nicotinamide and diethylamide of nicotinic acid stimulating effects on xenobiotic biotransformation in rat liver are assumed to be due to enhanced NADPH, glutathione and UDP-glucuronic acid biosynthesis as well as their antioxidant properties.
给大鼠皮下注射烟酰胺（50毫克/千克，持续5天），可使肝脏细胞色素b5的浓度、胞质溶胶和微粒体谷胱甘肽S -转移酶、UDP -葡萄糖醛酸基转移酶的活性以及结合型葡萄糖醛酸的尿排泄量分别增加26.7%、33.1%、33.3%、53.0%和31.0%。水合氯醛诱导的小鼠睡眠时间缩短了65%。在类似实验条件下，给予等摩尔量的烟酸二乙酰胺（75毫克/千克）产生了更显著的酶刺激作用。细胞色素P - 450浓度、胞质溶胶和微粒体谷胱甘肽S -转移酶、UDP -葡萄糖醛酸基转移酶的活性以及血浆中磺溴酞钠的消除和结合型葡萄糖醛酸的尿排泄量分别增加了37.0%、33.1%、54.6%、80.5%、24.5%和49.0%，而水合氯醛诱导的睡眠时间减少了75%。烟酰胺和烟酸二乙酰胺对大鼠肝脏中异生物质生物转化的刺激作用被认为是由于NADPH、谷胱甘肽和UDP -葡萄糖醛酸生物合成的增强及其抗氧化特性。
