Bushma M I, Legonkova L F, Abakumov G Z, Zavodnik L B
Vopr Pitan. 1994(6):12-5.
Increase of N-demethylase and antioxidant activities and decrease of amount of hydroperoxides were observed in liver of rats after intragastric administration of Undevit (1/8 dragee/rats/day, 5 times a week during 2 months). Combination of Undevit with Cordiamin (5 mg/rat/day) resulted in augmentation of cytochromes P-450 and b5 content and activities of their reductases, velocity of amidopyrine and ethylmorphine N-demethylation and oxidation of HADPH. Activities of UDP-glucuronyltransferase, glutathionetransferase and hydrophobity of microsomal membranes were also increased. Antioxidant activity was increased and amount of hydroperoxides in liver microsomes and homogenates and in plasma was decreased in greater degree after administration of combination two compounds than after administration of Undevit alone.
给大鼠灌胃服用复合维生素丸（1/8 片/大鼠/天，每周 5 次，持续 2 个月）后，观察到大鼠肝脏中 N-脱甲基酶活性和抗氧化活性增加，氢过氧化物含量减少。复合维生素丸与可拉明（5 毫克/大鼠/天）联合使用可增加细胞色素 P-450 和 b5 的含量及其还原酶的活性、氨基比林和乙基吗啡 N-脱甲基化速度以及 HADPH 的氧化。UDP-葡萄糖醛酸转移酶、谷胱甘肽转移酶的活性以及微粒体膜的疏水性也增加。与单独服用复合维生素丸相比，联合服用两种化合物后，肝脏微粒体和匀浆以及血浆中的抗氧化活性增加，氢过氧化物含量下降幅度更大。
