Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA.
Mov Disord. 2011 Jun;26(7):1274-81. doi: 10.1002/mds.23675. Epub 2011 Apr 19.
The aim of the present study was to investigate functional connectivity in focal hand dystonia patients to understand the pathophysiology underlying their abnormality in movement. We recorded EEGs from 58 electrodes in 15 focal hand dystonia patients and 15 healthy volunteers during rest and a simple finger-tapping task that did not induce any dystonic symptoms. We investigated mutual information, which provides a quantitative measure of linear and nonlinear coupling, in the alpha, beta, and gamma bands. Mean mutual information of all 58 channels and mean of the channels of interest representative of regional functional connectivity over sensorimotor areas (C3, CP3, C4, CP4, FCz, and Cz) were evaluated. For both groups, we found enhanced mutual information during the task compared with the rest condition, specifically in the beta and gamma bands for mean mutual information of all channels, and in all bands for mean mutual information of channels of interest. Comparing the focal hand dystonia patients with the healthy volunteers for both rest and task, there was reduced mutual information in the beta band for both mean mutual information of all channels and mean mutual information of channels of interest. Regarding the properties of the connectivity in the beta band, we found that the majority of the mutual information differences were from linear connectivity. The abnormal beta-band functional connectivity in focal hand dystonia patients suggests deficient brain connectivity.
本研究旨在通过记录 15 名局灶性手部震颤患者和 15 名健康志愿者在静息和简单手指敲击任务（不引起任何震颤症状）期间的脑电（EEG），来探究局灶性手部震颤患者的功能连接，以理解其运动异常的病理生理学机制。我们研究了互信息，这是一种提供线性和非线性耦合定量测量的方法，用于 alpha、beta 和 gamma 频段。评估了所有 58 个通道的平均互信息和代表感觉运动区域（C3、CP3、C4、CP4、FCz 和 Cz）的感兴趣通道的平均互信息。对于两组，我们发现与静息状态相比，在任务期间互信息增强，具体表现为所有通道的平均互信息的 beta 和 gamma 频段，以及感兴趣通道的平均互信息的所有频段。对于静息和任务状态下的局灶性手部震颤患者与健康志愿者进行比较，所有通道的平均互信息和感兴趣通道的平均互信息的 beta 波段的互信息均降低。关于 beta 波段连接的特性，我们发现大多数互信息差异来自线性连接。局灶性手部震颤患者的异常 beta 波段功能连接表明大脑连接不足。
