Department of Neurology, Columbia University Irving Medical Center and the New York Presbyterian Hospital, 650 W 168thStreet, Room 305, New York, NY, 10032, USA.
Initiative for Columbia Ataxia and Tremor, Columbia University Irving Medical Center, New York, NY, USA.
Cerebellum. 2023 Oct;22(5):985-1001. doi: 10.1007/s12311-022-01473-6. Epub 2022 Sep 7.
The cerebellum plays an important role in movement disorders, specifically in symptoms of ataxia, tremor, and dystonia. Understanding the physiological signals of the cerebellum contributes to insights into the pathophysiology of these movement disorders and holds promise in advancing therapeutic development. Non-invasive techniques such as electroencephalogram and magnetoencephalogram can record neural signals with high temporal resolution at the millisecond level, which is uniquely suitable to interrogate cerebellar physiology. These techniques have recently been implemented to study cerebellar physiology in healthy subjects as well as individuals with movement disorders. In the present review, we focus on the current understanding of cerebellar physiology using these techniques to study movement disorders.
小脑在运动障碍中起着重要作用,特别是在共济失调、震颤和肌张力障碍的症状中。了解小脑的生理信号有助于深入了解这些运动障碍的病理生理学,并有望推进治疗方法的发展。脑电图和脑磁图等非侵入性技术可以以毫秒级的高时间分辨率记录神经信号,非常适合研究小脑的生理机能。这些技术最近已被用于研究健康受试者和运动障碍患者的小脑生理机能。在本综述中,我们重点介绍了使用这些技术研究运动障碍时对小脑生理机能的现有认识。