He Fuyuan, Deng Kaiwen, Zou Huan, Qiu Yun, Chen Feng, Zhou Honghao
Property and pharmacodaynamic Key laboratory of TCMM, State Administration of Traditional Chinese Medicine, Department of Pharmaceutics, Hunan University of Tradition Chinese Medicine, Changsha 410208, China.
Zhongguo Zhong Yao Za Zhi. 2011 Jan;36(2):136-41.
To study on the differences between chromatopharmacokinetics (pharmacokinetics with fingerprint chromatography) and chromatopharmacodynamics (pharmacodynamics with fingerprint chromatography) of Chinese materia medica formulae to answer the question whether the pharmacokinetic parameters of multiple composites can be utilized to guide the medication of multiple composites.
On the base of established four chromatopharmacology (pharmacology with chromatographic fingerprint), the pharmacokinetics, and pharmacodynamics were analyzed comparably on their mathematical model and parameter definition.
On the basis of quantitative pharmacology, the function expressions and total statistical parameters, such as total zero moment, total first moment, total second moment of the pharmacokinetics, and pharmacodynamics were analyzed to the common expressions and elucidated results for single and multiple components in Chinese materia medica formulae. Total quantitative pharmacokinetic, i.e., chromatopharmacokinetic parameter were decided by each component pharmacokinetic parameters, whereas the total quantitative pharmacodynamic, i.e., chromatopharmacodynamic parameter were decided by both of pharmacokinetic and pharmacodynamic parameters of each components. The pharmacokinetic parameters were corresponded to pharmacodynamic parameters with an existing stable effective coefficient when the constitutive ratio of each composite was a constant.
The effects of Chinese materia medica were all controlled by pharmacokinetic and pharmacodynamic coefficient. It is a special case that the pharmacokinetic parameter could independently guide the clinical medication for single component whereas the chromatopharmacokinetic parameters are not applied to the multiple drug combination system, and not be used to solve problems of chromatopharmacokinetic of Chinese materia medica formulae.
研究中药复方的色谱药动学（指纹图谱色谱法的药动学）与色谱药效学（指纹图谱色谱法的药效学）之间的差异，以回答多种成分的药动学参数能否用于指导多种成分联合用药的问题。
在已建立的四种色谱药理学（色谱指纹图谱药理学）基础上，对药动学和药效学的数学模型及参数定义进行比较分析。
在定量药理学基础上，分析了药动学和药效学的函数表达式及总统计参数，如总零阶矩、总一阶矩、总二阶矩等，得出中药复方中单一成分和多种成分的通用表达式及阐明结果。总定量药动学即色谱药动学参数由各成分药动学参数决定，而总定量药效学即色谱药效学参数由各成分的药动学和药效学参数共同决定。当各组分的组成比例为常数时，药动学参数与药效学参数存在稳定的有效系数对应关系。
中药的效应均受药动学和药效学系数的控制。药动学参数可独立指导单一成分的临床用药，而色谱药动学参数不适用于多药联合系统，不能用于解决中药复方的色谱药动学问题，这是一种特殊情况。
