[地西泮对线粒体呼吸的影响]
[Effect of diazepam on mitochondrial respiration].
作者信息
di Jeso F, Truscello A, Martinotti G, di Jeso B, Magnani B, Martinotti A
机构信息
Université de Pavie, Faculté de Médecine, Dépt. Biochimie, Italie.
出版信息
C R Seances Soc Biol Fil. 1990;184(1):37-40.
Our hypothesis that the strong effects of neutropic drugs on nervous system have hidden more widespread effects on all tissues and cells, is collecting evidences in our laboratory. We have essayed in vitro benzodiazepines on liver rat mitochondria. The present work deals with experiments on diazepam: it depresses the respiration coupled to phorphorylation in mitochondria having a good respiratory control; so respiratory control too is depressed. Also P/O ratio is lowered.
我们的假说，即神经营养药物对神经系统的强烈作用对所有组织和细胞隐藏着更广泛的影响，正在我们实验室收集证据。我们已经在体外对大鼠肝脏线粒体进行了苯二氮䓬类药物实验。目前的工作涉及地西泮的实验：它抑制了具有良好呼吸控制的线粒体中与磷酸化偶联的呼吸作用；因此呼吸控制也受到抑制。同时，磷氧比也降低了。
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