Emergency Department, Tehran University of Medical Sciences, Tehran, Iran.
Hum Exp Toxicol. 2012 May;31(5):518-22. doi: 10.1177/0960327111407229. Epub 2011 Apr 20.
Aluminum phosphide (ALP), as an effective pesticide and a substance used for protecting rice during storage, has become one of the commonest causes of poisoning and even suicide in developing countries including Iran and India. The authors aimed to study the efficacy of sweet almond oil as an antidote in ALP toxicity.
The present experimental study was conducted over 35 rats. The animals were divided into four groups: one group as the control group and three other groups which received ALP alone or ALP and sweet almond oil with different time intervals. In addition to estimating the survival rate of the animals, plasma cholinesterase activity as a possible factor affected in ALP poisoning was evaluated.
Treatment by intragastric irrigation of sweet almond oil resulted in significant reduction of mortality. Moreover, mean plasma cholinesterase levels were inhibited in groups receiving ALP.
Oral sweet almond oil, if especially used immediately after poisoning with ALP, improves the survival rate.
磷化铝（ALP）作为一种有效的杀虫剂和储粮保护剂，已成为包括伊朗和印度在内的发展中国家中毒甚至自杀的常见原因之一。作者旨在研究甜杏仁油作为 ALP 毒性解毒剂的功效。
本实验研究共涉及 35 只大鼠。这些动物被分为四组：一组作为对照组，三组分别单独接受 ALP 或 ALP 与甜杏仁油，且间隔时间不同。除了评估动物的存活率外，还评估了血浆胆碱酯酶活性这一可能受 ALP 中毒影响的因素。
通过胃内灌洗甜杏仁油进行治疗，可显著降低死亡率。此外，接受 ALP 治疗的组的平均血浆胆碱酯酶水平受到抑制。
口服甜杏仁油，如果在摄入 ALP 后立即使用，可提高存活率。
