Saidi Hossein, Shokraneh Farhad, Ghafouri Hamed-Basir, Shojaie Shayan
Assistant Professor, Department of Emergency, Rasoul-e-Akram Hospital, Tehran University of Medical Sciences, Tehran, Iran.
J Res Med Sci. 2011 Oct;16(10):1306-12.
Aluminium phosphide (AlP) is used as a fumigant. It produces phosphine gas which is a mitochondrial poison. Although this poisoning has been repeatedly reported in literature with a high mortality rate, there is no known antidote for AlP intoxication. In the present study, we studied the effects of hyperbaric oxygenation (HBO) on the survival time of AlP intoxicated rats.
Intoxicated rats with AlP (11.5 mg/kg, oral gavage) were placed in hyperbaric oxygenation with different concentrations of compressed air and oxygen.
All the animals exposed to AlP died within 5 days. The mean survival times of rats exposed to AlP without any intervention, treated with hyperbaric condition by compressed air, and treated with hyperbaric condition by pure O2 were 91 ± 1, 262 ± 8, and 276 ± 6 minutes, respectively. In analysis of survival times, there was a significant difference between Group 2 which received AlP and the groups which underwent intervention (Groups 2 and 3, p < 0.001; Groups 2 and 4, p < 0.001).
Hyperbaric oxygenation may probably improve the survival time of the intoxicated rats with aluminium phosphide, but it may not decrease the mortality rate.
磷化铝用作熏蒸剂。它会产生磷化氢气体，这是一种线粒体毒物。尽管这种中毒在文献中已被多次报道，死亡率很高，但目前尚无已知的磷化铝中毒解毒剂。在本研究中，我们研究了高压氧疗（HBO）对磷化铝中毒大鼠存活时间的影响。
将经磷化铝（11.5mg/kg，经口灌胃）中毒的大鼠置于不同浓度压缩空气和氧气的高压氧环境中。
所有接触磷化铝的动物均在5天内死亡。未进行任何干预、接受压缩空气高压处理以及接受纯氧高压处理的磷化铝中毒大鼠的平均存活时间分别为91±1分钟、262±8分钟和276±6分钟。在存活时间分析中，接受磷化铝处理的第2组与接受干预的组（第2组和第3组，p<0.001；第2组和第4组，p<0.001）之间存在显著差异。
高压氧疗可能会延长磷化铝中毒大鼠的存活时间，但可能不会降低死亡率。
