Department of Internal Medicine, Medical University of Graz, Auenbruggerplatz 15, 8036 Graz, Austria.
Anticancer Res. 2011 Apr;31(4):1373-7.
Integrins influence tumourigenesis, tumor progression and development of metastases. The impact of polymorphisms in integrin genes on relapse-free survival (RFS) and overall survival (OS) for 433 Caucasian patients with colorectal cancer was analysed in this retrospective study.
A Cox regression model including integrin genotype, age, grading, tumour size, number of lymph nodes examined, number of metastatic lymph nodes, stage and application of fluorouracil-based adjuvant chemotherapy was used to estimate their effect.
After a median follow-up of 41 months for RFS and 55 months for OS, no significant correlation between the ITGA2 1648A allele (RFS p=0.618, OS p=0.604), the ITGA2 807T allele (RFS p=0.603, OS p=0.807) and the ITGB3 176C allele (RFS p=0.719, OS p=0.261) and survival was detectable.
The investigated integrin polymorphisms are not associated with RFS or OS in colorectal cancer patients.
整合素影响肿瘤发生、肿瘤进展和转移的发展。本回顾性研究分析了整合素基因多态性对 433 例白人结直肠癌患者无复发生存（RFS）和总生存（OS）的影响。
使用 Cox 回归模型，包括整合素基因型、年龄、分级、肿瘤大小、检查的淋巴结数量、转移性淋巴结数量、分期和氟尿嘧啶辅助化疗的应用，以估计其效果。
RFS 随访中位数为 41 个月，OS 随访中位数为 55 个月，未发现 ITGA2 1648A 等位基因（RFS p=0.618，OS p=0.604）、ITGA2 807T 等位基因（RFS p=0.603，OS p=0.807）和 ITGB3 176C 等位基因（RFS p=0.719，OS p=0.261）与生存之间存在显著相关性。
研究中发现的整合素多态性与结直肠癌患者的 RFS 或 OS 无关。
