Gerger Armin, Hofmann Günter, Langsenlehner Uwe, Renner Wilfried, Weitzer Werner, Wehrschütz Martin, Wascher Thomas, Samonigg Hellmut, Krippl Peter
Division of Oncology, Department of Internal Medicine, Medical University of Graz, Auenbruggerplatz 15, 8036, Graz, Austria.
Int J Colorectal Dis. 2009 Feb;24(2):159-63. doi: 10.1007/s00384-008-0587-9. Epub 2008 Oct 3.
Integrins such as alpha(2)beta(1), alpha(IIb)beta(3), and alpha(v)beta(3) have been suggested as key players for cancer development and progression. Several polymorphisms affecting these molecules, two in integrin alpha(2) (ITGA2 807C>T and 1648G>A) and one in beta(3) (ITGB3 176T>C), influence their levels, structure, and possibly their function. To analyze the role of ITGA2 and ITGB3 polymorphisms for colorectal cancer risk and clinical presentation, we performed a case-control study.
Four hundred thirty-three colorectal cancer patients and 433 healthy sex- and age-matched control subjects were investigated. ITGA2 and ITGB3 polymorphisms were determined by 5'-nuclease assays.
RESULTS/FINDINGS: The ITGA2 807C>T polymorphism was associated with reduced colorectal cancer risk. In a codominant model, the odds ratio for each additional 807-T allele for colorectal cancer was 0.77 (95% confidence interval 0.64-0.94; p = 0.011). The ITGA2 1648G> and the ITGB3 176T>C polymorphism were not associated with colorectal cancer. None of the three polymorphisms investigated was associated with tumor size, histological grade, presence of primary lymph node metastases, tumor stage, or age at diagnosis.
INTERPRETATION/CONCLUSION: We conclude that the ITGA2 807C>T polymorphism may be associated with reduced colorectal cancer risk.
整合素如α(2)β(1)、α(IIb)β(3)和α(v)β(3)被认为是癌症发生和发展的关键因素。影响这些分子的几种多态性，整合素α(2)中的两种（ITGA2 807C>T和1648G>A）以及β(3)中的一种（ITGB3 176T>C），会影响它们的水平、结构以及可能的功能。为了分析ITGA2和ITGB3多态性在结直肠癌风险和临床表现中的作用，我们进行了一项病例对照研究。
对433例结直肠癌患者和433例年龄及性别匹配的健康对照者进行了调查。通过5'-核酸酶分析确定ITGA2和ITGB3多态性。
结果/发现：ITGA2 807C>T多态性与结直肠癌风险降低相关。在共显性模型中，结直肠癌患者每增加一个807-T等位基因的优势比为0.77（95%置信区间0.64 - 0.94；p = 0.011）。ITGA2 1648G>和ITGB3 176T>C多态性与结直肠癌无关。所研究的三种多态性均与肿瘤大小、组织学分级、原发性淋巴结转移的存在、肿瘤分期或诊断时的年龄无关。
解释/结论：我们得出结论，ITGA2 807C>T多态性可能与结直肠癌风险降低相关。
