Manor R S, Bar-Ziv J, Tadmor R, Eisbruch A, Rechavi G
Neuro-ophthalmology Unit, Beilinson Medical Center, Petah Tikva, Israel.
J Clin Neuroophthalmol. 1990 Dec;10(4):239-43.
A 13-year-old boy presented with blindness and loss of the papillomacular bundle in the left eye, bilateral papilledema sparing the area of axonal loss, and Parinaud's syndrome. Computerized tomography (CT) revealed an enlarged kinked left optic nerve and enlarged optic canal as well as a tumor in the pineal area producing hydrocephalus. Magnetic resonance (MR) scans showed multiple spinal metastases. The histological diagnosis was germinoma. On completion of four courses of chemotherapy with cis-platin, vinblastine, and bleomycin, repeated CT of orbita and MR imaging of the spine demonstrated the disappearance of the tumor surrounding the left optic nerve and of the spinal metastases. This is believed to be the first case report of seeding of germinoma into the perioptic arachnoid space.
一名13岁男孩出现左眼失明及视乳头黄斑束缺失、双侧视乳头水肿（未累及轴突缺失区域）和帕里诺德综合征。计算机断层扫描（CT）显示左侧视神经迂曲增粗、视神经管扩大，以及松果体区有一肿瘤导致脑积水。磁共振成像（MR）扫描显示多发脊柱转移瘤。组织学诊断为生殖细胞瘤。在用顺铂、长春碱和博来霉素完成四个疗程化疗后，眼眶重复CT及脊柱MR成像显示围绕左侧视神经的肿瘤及脊柱转移瘤消失。据信这是生殖细胞瘤播散至视神经周围蛛网膜下腔的首例病例报告。
