Mann D M, Royston M C, Ravindra C R
Department of Pathological Sciences, University of Manchester, U.K.
J Neurol Sci. 1990 Nov;99(2-3):153-64. doi: 10.1016/0022-510x(90)90152-d.
The number of senile plaques (SP) and neurofibrillary tangles (NFT) and the number and nucleolar volume of nerve cells have been estimated in certain cortical and subcortical regions in 22 patients with Down's syndrome (DS) and have been related to the patients' age and to the presence and severity of dementia. Elderly (i.e. over 50 years of age) patients showed increased densities of SP and NFT and significant reductions in number and nucleolar volume of nerve cells, when compared with patients under 50 years of age, though the extent of these changes was, in general, no greater in the non-demented elderly group than that in the demented elderly group. Of the younger, nondemented group, those patients with a limited formation of SP and NFT in their brains showed a similar number and nucleolar volume of nerve cells, as those completely devoid of SP and NFT. It is concluded that in DS, formation of SP and NFT predate any significant atrophy and loss of nerve cells and that it is only after the age of 50 years that gross atrophy and loss of neurones occurs, though the extent of this process seemingly does not predict the onset, nor the progress, of dementia.
在22例唐氏综合征（DS）患者的某些皮质和皮质下区域，对老年斑（SP）和神经原纤维缠结（NFT）的数量以及神经细胞的数量和核仁体积进行了评估，并将其与患者的年龄以及痴呆的存在和严重程度相关联。与50岁以下的患者相比，老年（即50岁以上）患者的SP和NFT密度增加，神经细胞数量和核仁体积显著减少，尽管一般而言，这些变化的程度在非痴呆老年组中并不比痴呆老年组更大。在较年轻的非痴呆组中，那些大脑中SP和NFT形成有限的患者，其神经细胞数量和核仁体积与那些完全没有SP和NFT的患者相似。得出的结论是，在唐氏综合征中，SP和NFT的形成早于任何明显的神经细胞萎缩和损失，并且只有在50岁以后才会出现明显的神经元萎缩和损失，尽管这个过程的程度似乎并不能预测痴呆的发作和进展。
