伊朗德黑兰多发性硬化症的 20 年发病趋势（1989-2008 年）和时点患病率（2009 年 3 月 20 日）：一项基于人群的研究。

A 20-year incidence trend (1989-2008) and point prevalence (March 20, 2009) of multiple sclerosis in Tehran, Iran: a population-based study.

机构信息

Department of Epidemiology and Biostatistics, Tehran University of Medical Sciences, Tehran, Iran.

出版信息

Neuroepidemiology. 2011;36(3):141-7. doi: 10.1159/000324708. Epub 2011 Apr 20.

DOI:10.1159/000324708

PMID:21508646

Abstract

BACKGROUND

The frequency of multiple sclerosis (MS) is still undetermined in Tehran. We conducted this survey to assess the incidence trend and point prevalence of MS on March 20, 2009, in Tehran province, Iran.

METHODS

Data for patients with a definite diagnosis of MS were obtained from the Iranian MS Society (IMSS). The annual incidence rates were calculated based on year of diagnosis. The prevalence and annual incidence rates were standardized using the WHO (2000-2025) population as a standard.

RESULTS

We detected 8,026 definite MS cases that had been registered by the IMSS till the prevalence day. The age- and sex-adjusted incidence rates increased significantly from 0.68/100,000 in 1989 to 2.93/100,000 in 2008 with its peak (4.58) in 2005. On March 20, 2009, we identified 7,896 prevalent cases (5,888 females and 2,008 males) yielding an age-adjusted prevalence rate of 50.57/100,000 (females: 77.24 and males: 25.54). The female-to-male ratio was 3.11 (95% confidence interval: 2.95-3.27). The age-specific prevalence showed a peak in the group aged 35-39 years in females and in that of 40-44 years in males with a mean (±SD) age of 35.48 (±9.9) years for females and 36.98 (±10.5) years for males.

CONCLUSION

Tehran is a high-risk area for MS disease, and the incidence has dramatically increased over the last 20 years.

摘要

背景

多发性硬化症（MS）在德黑兰的发病率仍不确定。我们进行了这项调查，以评估 2009 年 3 月 20 日伊朗德黑兰省 MS 的发病趋势和现患率。

方法

从伊朗多发性硬化症协会（IMSS）获得明确诊断为 MS 的患者数据。根据诊断年份计算年度发病率。使用世界卫生组织（2000-2025）人口作为标准对患病率和年度发病率进行标准化。

结果

我们发现，截至流行日，IMSS 登记的明确 MS 病例为 8026 例。年龄和性别调整后的发病率从 1989 年的 0.68/100000 显著增加到 2008 年的 2.93/100000，2005 年达到峰值（4.58）。2009 年 3 月 20 日，我们发现 7896 例现患病例（5888 名女性和 2008 名男性），年龄调整后的患病率为 50.57/100000（女性：77.24，男性：25.54）。女性与男性的比例为 3.11（95%置信区间：2.95-3.27）。特定年龄的患病率在女性 35-39 岁组和男性 40-44 岁组中达到峰值，女性的平均（±SD）年龄为 35.48（±9.9）岁，男性为 36.98（±10.5）岁。