Del Carmen Marcela G, Boruta David M, Schorge John O
Division of Gynecologic Oncology, Vincent Obstetrics and Gynecology Service, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Clin Obstet Gynecol. 2011 Jun;54(2):266-77. doi: 10.1097/GRF.0b013e318218c6d1.
Endometrial cancer is the most common gynecologic malignancy in the United States. The majority of women are diagnosed with early-stage, low-grade endometrioid tumors that are highly curable with primary surgery. Patients with more advanced and/or higher grade disease require multimodality therapy and have a higher risk for recurrence. Although uterine papillary serous carcinoma and clear cell carcinoma are diagnosed infrequently, they account for almost half of all relapses. As women with recurrent endometrial cancer constitute a heterogeneous group, an individualized approach is required. We review the treatment options of surgery, radiation, hormonal therapy, cytotoxic chemotherapy, and biological agents.
子宫内膜癌是美国最常见的妇科恶性肿瘤。大多数女性被诊断为早期、低级别子宫内膜样肿瘤，通过初次手术即可高度治愈。患有更晚期和/或更高级别疾病的患者需要多模式治疗，且复发风险更高。尽管子宫浆液性乳头状癌和透明细胞癌的诊断并不常见，但它们几乎占所有复发病例的一半。由于复发性子宫内膜癌患者构成一个异质性群体，因此需要采取个体化的治疗方法。我们回顾了手术、放疗、激素治疗、细胞毒性化疗和生物制剂等治疗选择。
