Ray Mandira, Fleming Gini
Department of Medicine, Section of Hematology/Oncology, University of Chicago, Chicago, IL 60637, USA.
Semin Oncol. 2009 Apr;36(2):145-54. doi: 10.1053/j.seminoncol.2008.12.006.
Endometrial carcinoma is frequently diagnosed at an early stage, at which point it is usually surgically curable. Some less common subtypes of endometrial carcinoma, such as serous and clear cell carcinomas, have a worse prognosis than most endometrioid carcinomas. Patients with advanced or recurrent disease, regardless of histologic subtype, have a poor prognosis. Both single-agent and combination chemotherapy regimens (such as doxorubicin, cisplatin, and paclitaxel) have antitumor activity but are not curative. Recently, adjuvant chemotherapy has been shown to improve outcomes in high-risk nonmetastatic (stage III) disease. Newer agents such as mammalian target of rapamycin (mTOR) inhibitors show promise, and are currently being tested in a clinical trials.
子宫内膜癌通常在早期被诊断出来，此时通过手术通常可以治愈。一些不太常见的子宫内膜癌亚型，如浆液性癌和透明细胞癌，其预后比大多数子宫内膜样癌更差。患有晚期或复发性疾病的患者，无论组织学亚型如何，预后都很差。单药和联合化疗方案（如阿霉素、顺铂和紫杉醇）都具有抗肿瘤活性，但不能治愈。最近，辅助化疗已被证明可改善高危非转移性（III期）疾病的治疗效果。新型药物如雷帕霉素靶蛋白（mTOR）抑制剂显示出前景，目前正在临床试验中进行测试。
