Thompson Matthew P, Pinckard J Keith
From the *Department of Pathology, University of Texas Southwestern Medical Center; and †Southwestern Institute of Forensic Sciences, Dallas, TX.
Am J Forensic Med Pathol. 2011 Sep;32(3):232-5. doi: 10.1097/PAF.0b013e318219ca5b.
Thyrotoxic periodic paralysis is a rare and dramatic complication of hyperthyroidism. Thyrotoxic periodic paralysis classically presents with proximal lower limb weakness in the setting of hypokalemia and thyrotoxicosis. Thyrotoxic periodic paralysis represents an endocrine emergency with a rapidly ascending paralysis that can result in respiratory insufficiency, cardiac arrhythmias, and death if not accurately and rapidly diagnosed. We report a case of undiagnosed fatal thyrotoxic periodic paralysis presenting to the medical examiner. The diagnosis was made primarily by review of the clinical history.
甲状腺毒症性周期性瘫痪是一种罕见且严重的甲状腺功能亢进并发症。典型的甲状腺毒症性周期性瘫痪表现为在低钾血症和甲状腺毒症背景下出现近端下肢无力。甲状腺毒症性周期性瘫痪是一种内分泌急症,其瘫痪迅速进展,若未得到准确快速诊断,可导致呼吸功能不全、心律失常甚至死亡。我们报告一例提交给法医的未被诊断出的致命性甲状腺毒症性周期性瘫痪病例。诊断主要通过回顾临床病史得出。