Kisoka G, Bertrand X
Département des Urgences, CHR Citadelle, Liège, Belgique.
Rev Med Liege. 2019 Jan;74(1):20-22.
Periodic thyrotoxic paralysis (TPP) is a disease that usually affects Asian men from 20 to 50 years. It is secondary to genetic mutations of ion channels for the transport of sodium and potassium. It is characterized by recurrent and brutal bouts of paresis / flaccid paralysis, without sensory involvement, in a context of hyperthyroidism. Seizures preferentially affect proximal muscles and are often associated with severe hypokalemia. However, serious repercussions are rare, except in cases of extreme weakness of the respiratory muscles or cardiac arrhythmia induced by hypokalemia. The treatment of ionic disorders, followed by the correction of hyperthyroïdism, leads to the complete disappearance of symptoms.
周期性甲状腺毒症性麻痹（TPP）是一种通常影响20至50岁亚洲男性的疾病。它继发于钠和钾转运离子通道的基因突变。其特征是在甲状腺功能亢进的情况下，反复出现且突然发作的轻瘫/弛缓性麻痹，无感觉障碍。发作优先累及近端肌肉，常伴有严重低钾血症。然而，严重后果很少见，除非出现呼吸肌无力或低钾血症引起的心律失常等极端情况。纠正离子紊乱，随后纠正甲状腺功能亢进，可使症状完全消失。
