Sasaki E
Department of Dermatology, Nippon Medical School, Bunkyo-ku, Tokyo, Japan.
Contact Dermatitis. 1990 Nov;23(5):306-15. doi: 10.1111/j.1600-0536.1990.tb05164.x.
506 patients were suspected of being allergic to corticosteroid medicaments in our clinic during the 22 years from 1967 to 1988. Patch tests were performed in these patients. Scratch tests, intradermal tests, and challenge tests were also carried out in some cases. 69 patients showed positive reactions to corticosteroid products (as is). 18 were allergic to the corticosteroid itself and 44 were sensitive to vehicle components or other active ingredients. In 7 cases, the allergen could not be detected. Patients who were allergic to corticosteroids were tested for their cross-sensitivity with our corticosteroid patch test series. Cross-reactions tended to occur between members of the same corticosteroid type, and some of the combinations of different corticosteroid types cross-reacted with each other. Corticosteroid-sensitive cases have increased in number during these 22 years. Corticosteroid sensitivity is not as rare as formerly thought.
1967年至1988年的22年间，我院有506例患者疑似对皮质类固醇药物过敏。对这些患者进行了斑贴试验。在某些情况下还进行了划痕试验、皮内试验和激发试验。69例患者对皮质类固醇产品呈阳性反应（原样）。18例对皮质类固醇本身过敏，44例对赋形剂成分或其他活性成分敏感。7例中未检测到过敏原。对皮质类固醇过敏的患者用我们的皮质类固醇斑贴试验系列检测其交叉敏感性。交叉反应倾向于在同一类型的皮质类固醇成员之间发生，并且不同类型皮质类固醇的一些组合相互交叉反应。在这22年中，对皮质类固醇敏感的病例数量有所增加。皮质类固醇敏感性并不像以前认为的那样罕见。
